Kokristali u farmaceutskoj industriji

undergraduate thesis

• Title (english): Co-crystals in pharmaceutical industry
• Author: Matea Lilić
• Mentor: Jasna Prlić Kardum (mentor)
• Committee member: Jasna Prlić Kardum (predsjednik povjerenstva)
• Committee member: Aleksandra Sander (član povjerenstva)
• Committee member: Lidija Furač (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2017-09-22, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering; Mechanical, Thermal and Separation Processes

Abstract

Na farmaceutskom tržištu postoje lijekovi različitih oblika,sastava i namjena. Poboljšavanje njihovih fizikalno-kemijskih svojstva glavni je cilj istraživanja u farmaceutskoj industriji. Vodeći problemi jesu loša topljivost lijekova i njihova slaba bioraspoloživost, zbog kojih na tržište dospije manje od 1 % djelatnih farmaceutskih tvari. Moguće rješenje nudi se u primjeni kokristalizacije u kristalnom inženjerstvu kojom se omogućuje modificiranje i poboljšavanje fizikalno-kemijskih svojstva djelatnih farmaceutskih tvari uz istodobno zadržavanje intrizične aktivnosti i strukture molekule lijeka.

Abstract (english)

There are many drugs on pharmaceutical market characterized by different solid state, composition and purpose. Enhancement of their physicochemical properties is one of the main goals of many researches in pharmaceutical industry. Main issues are low solubility and poor bioavailability of drugs, causing that less then 1% of active pharmaceutical ingredients reaches the market. Application of co-crystallization in crystallization engineering can possibly provide solutions to these challenges by modifications and improvement of physicochemical properties of the active pharmaceutical ingredients while maintaining the intrinsic activity of the drug molecule.

• Keywords: bioraspoloživost; djelatne farmaceutske tvari; kokristalizacija; topljivost
• Keywords (english): bioavailability; active pharmaceutical ingredients; co-crystallization; solubility
• Language: croatian
• URN:NBN: urn:nbn:hr:149:512146
• Study programme: Title: Environmental Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Public note: Na glavnoj naslovnoj stranici rada naveden je pogrešan naslov rada: Kokristalizacija u farmaceutskoj industriji
• Created on: 2021-03-30 12:16:05