Raspodjela veziva u granulama dobivenim taljenjem u fluidiziranom sloju

undergraduate thesis

• Title (english): Binder distribution in granules obtained by melting in fluidized bed
• Author: Valentino Subotičanec
• Mentor: Krunoslav Žižek (mentor)
• Committee member: Krunoslav Žižek (predsjednik povjerenstva)
• Committee member: Gordana Matijašić (član povjerenstva)
• Committee member: Vesna Ocelić Bulatović (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2018-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering; Mechanical, Thermal and Separation Processes

Abstract

Ovim istraživanjem sagledano je granuliranje u fluidiziranom sloju s in-situ taljenjem veziva kao moguća procesna tehnologija za pripravu mješavine azitromicin dihidrata i laktoze monohidrata pogodne za izradu tableta dobrih primjenskih svojstava. Dodatni ulazni procesni tokovi su zrak i čvrsti polietilen glikol (vezivo) čiji kolektiv kapljica nastaje in-situ taljenjem. Studij fenomena granuliranja u laboratorijskom mjerilu usmjeren je k pronalaženju uvjeta provedbe procesa, geometrije raspršivanja i svojstava ulaznih procesnih tokova koji će sinergističkim djelovanjem upravljati mikro- i mezorazinskim događajima na povoljan i željeni način te time rezultirati kolektivom postojanih okrupnjenih jedinki, granula laktoze monohidrata u čiju je matricu ugrađena djelatna tvar, azitromicin dihidrat. Uspješno granuliranje provedeno je in-situ taljenjem veziva. Dobiveni su kolektivi većih veličina čestica te izvrsne tecivosti. Termogravimetrijskom analizom određen je sadržaj veziva u granulama različitih veličina. Također, sagledana je raspodjela sadržaja veziva među granulama različitih veličinskih razreda.

Abstract (english)

With this study, fluidized bed granulation by in-situ binder melting is scrutinized as a potential process technology for preparation of azithromycin dihydrate and lactose monohydrate mixture that is suitable for manufacturing of tablets with good end-use properties. Additional inlet process streams are air and solid polyethylene glycol (binder), whose droplet population is formed using in-situ melting. Study of the granulation phenomenon in a lab-scale is focused towards detection of process conditions, spraying geometry and formulation properties that will synergically drive micro- and meso-scale events in a favourable and desired way and therewith result in a collective of stable enlarged entities, lactose monohydrate granule matrices in which the active substance, azithromycin dihydrate, is incorporated. Successful granulation is carried out for in-situ binder melting. Collectives of higher particle sizes and excellent flowability have been obtained. Binder content has been detected in granules of different sizes using thermogravimetric analysis. Binder content distribution among granule sizes has been discussed as well.

• Keywords: granuliranje u fluidiziranom sloju; in-situ taljenje; laktoza monohidrat; azitromicin dihidrat; polietilen glikol; raspodjela sadržaja veziva
• Keywords (english): fluidized bed granulation; in-situ melting; lactose monohydrate; azithromycin dihydrate; polyethylene glycol; binder content distribution
• Language: croatian
• URN:NBN: urn:nbn:hr:149:692890
• Study programme: Title: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Environmental chemistry and green technologies; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-06-23 12:05:53