Sorpcija cefdinira na prirodne uzorke tla i sedimente

undergraduate thesis

• Title (english): Sorption of cefdinir on natural soil and sediment samples
• Author: Mia Gotovuša
• Mentor: Dragana Mutavdžić Pavlović (mentor)
• Committee member: Dragana Mutavdžić Pavlović (predsjednik povjerenstva)
• Committee member: Šime Ukić (član povjerenstva)
• Committee member: Marijana Hranjec (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2018-09-06, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry; Analytic Chemistry

Abstract

Napredovanjem istraživanja i razvojem farmaceutske industrije, broj otkrivenih farmaceutski aktivnih tvari s vremenom sve više raste. Novootkriveni farmaceutici putem otpadnih tokova mogu dospjeti u okoliš i onečistiti ga. Poznavanje fizikalno-kemijskih svojstava farmaceutika te procesa razgradnje kojima podliježu u okolišu, ključno je za predviđanje njihova ponašanja. Jedan od takvih neistraženih farmaceutika je i cefdinir. Pripadnik je treće generacije antibiotika cefalosporina, a najveću primjenu pronalazi u liječenju bakterijskih infekcija uha, sinusa, grla i kože. Sorpcija je primjer procesa kojem ovaj farmaceutik podliježe u okolišu. Cefdinir se može sorbirati na prirodna tla i sedimente, a intenzitet sorpcije pritom će ovisiti o čimbenicima poput ionske jakosti, pH-vrijednosti te vremena sorpcije. Cilj ovog završnog rada bio je kroz niz eksperimenata ispitati proces sorpcije cefdinira na prirodna tla i sedimente, uzorkovane diljem Republike Hrvatske. Eksperimentalni su podatci opisani modelima sorpcijskih izotermi - Linearnim, Freundlichovim te Dubinin-Radushkevichevim modelom – pri čemu je najviša vrijednost koeficijenta korelacije (R2 > 0,99) dobivena Linearnim modelom. Koeficijent sorpcije (Kd) pokazao se najmanjim za sediment Pakru i tlo Gračac, a najvećim za sediment Lonju i tlo Josipovac. S porastom ionske jakosti i pH-vrijednosti, vrijednost koeficijenta sorpcije se smanjuje. Za opis kinetike sorpcije cefdinira korišteni su pseudokinetički modeli 1. i 2. reda. Pritom je najbolje slaganje s eksperimentalnim podatcima za sediment Glinu i tlo Bruvno pokazao pseudokinetički model 2. reda. Desorpcija cefdinira opisana je modelom međučestične difuzije prema kojem je konstanta brzine međučestične difuzije za tlo Bruvno veća od konstante za sediment Glinu. Vrijednosti konstante brzine to su veće što je veća početna koncentracija standardne otopine cefdinira.

Abstract (english)

By expanding the research and development of the pharmaceutical industry, the number of pharmaceutically active substances discovered over time is growing. Newly discovered pharmaceuticals can get into the environment through waste streams and cause its contamination. Knowing the physicochemical properties of the pharmaceuticals and the degradation processes they are subject to in the environment is crucial for predicting their behavior. One of such unexplored pharmaceuticals is cefdinir. Cefdinir is a third-generation cephalosporin antibiotic, and finds the greatest use in the treatment of bacterial infections of the ear, sinus, throat and skin. Sorption is an example of a process that this drug is subject to in the environment. Cefdinir can be sorbed on natural soil and sediments, and sorption intensity will depend on factors such as ionic strength, pH-value and sorption time. Through a series of experiments, the aim of this study was to examine the process of sorption of cefdinir on natural soil and sediments sampled throughout the Republic of Croatia. The experimental data are described by the models of sorption isotherms - Linear, Freundlich and Dubinin – Radushkevich model – of which the highest correlation coefficient (R2> 0.99) was obtained with a Linear model. The sorption coefficient (Kd) proved to be the lowest for sediment Pakra and the soil of Graĉac, and the highest for sediment Lonja and soil Josipovac. With the increase in ionic strength and pH-value, the value of the sorption coefficient decreases. In order to describe the kinetics of absorption of cefdinir, the pseudo first order model and the pseudo second order model were used. The best correlation with experimental data for the sediment of Glina and the soil of Bruvno was given with the pseudo second order model. The desorption of cefdinir is described by an intra particle diffusion model according to which the intraparticle diffusion rate constant for the soil of Bruvno is greater than the one for the sediment of Glina. The higher the initial concentration of the standard cefdinir solution, the larger the value of the intraparticle rate constant.

• Keywords: sorpcija; cefdinir; tlo; sediment; ionska jakost; pH-vrijednost; koeficijent sorpcije
• Keywords (english): sorption; cefdinir; soil; sediment; ionic strength; pH-value; sorption coefficient
• Language: croatian
• URN:NBN: urn:nbn:hr:149:563105
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-06-24 11:14:50