Optimizacija procesa kristalizacije fosamprenavir-kalcija

master's thesis

• Title (english): Optimization of the crystallization process for fosamprenavir calcium
• Author: Luka Đuran
• Mentor: Jasna Prlić Kardum (mentor)
• Committee member: Jasna Prlić Kardum (predsjednik povjerenstva)
• Committee member: Aleksandra Sander (član povjerenstva)
• Committee member: Nenad Bolf (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2020-09-30, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Farmaceutska industrija svakodnevno koristi procese kristalizacije za pripremu djelatnih tvari korištenih u medicinske svrhe. Fosamprenavir i njegove soli značajni su u borbi protiv virusa humane imunodeficijencije, što čini poznavanje njihovih metoda pripreme i karakterizacije od izrazite važnosti. U ovom radu ispitane su različite metode kristalizacije djelatne tvari fosamprenavir-kalcija, kao i odabir pogodnih otapala i antiotapala te njihov utjecaj na granulometrijska svojstva i polimorfiju kristala. Utvrđeno je da metoda kristalizacije uz dodatak antiotapala pokazuje veču učinkovitost od metode kristalizacije hlađenjem za ispitane sustave otapala, te da su kristali dobiveni metodom uz dodatak antiotapala prikladniji za daljnje separacijske procese. Ustanovljeno je da se iskorištenje veće od 90 % ostvaruje pri dodavanju 36 % volumnog udjela vode ispitivanim smjesama otapala. Različiti procesni uvjeti, kao i korištena otapala, imali su značajan utjecaj na pojavu smjese polimorfnih oblika fosamprenavir-kalcija, što je utvrđeno analizom rendgenske difrakcije dobivenih kristala.

Abstract (english)

Using crystallization processes for development of active pharmaceutical ingredients (API) used for medicinal purposes is commonplace in the pharmaceutical industry. Fosamprenavir and its salts show importance in treating the symptoms of human immunodefficiency virus infections, which makes their methods of preparation and characterization of great significance. In this research different methods of crystallization of fosamprenavir calcium, suitable solvents and antisolvents and their effect on crystal granulometric properties and polimorfy were investigated. Antisolvent crystallization was shown to be more efficient than cooling crystallization for all investigated solvent mixtures, and crystals produced with antisolvent method were found to be preferable for further separation processes. Procces efficiency of over 90 % for 36 % volume fraction of antisolvent added to solvent mixtures was shown. Presence of polymorfic mixtures in the prepared crystals was significantly influenced by operating conditions and chosen solvent mixtures, as was found in X-ray diffraction analysis.

• Keywords: fosamprenavir-kalcij; granulometrijska svojstva kristala; kristalizacija uz dodatak antiotapala; kristalizacija hlađenjem
• Keywords (english): fosamprenavir calcium; granulometric properties; antisolvent crystalization; cooling crystallization
• Language: croatian
• URN:NBN: urn:nbn:hr:149:374407
• Study programme: Title: Chemical Engineering - Graduate study; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Closed access
• Created on: 2022-03-02 12:37:55