Hidrolitička razgradnja norfloksacina u okolišu

master's thesis

• Title (english): Hydrolytic degradation of norfloxacin in the environment
• Author: Karla Grošić
• Mentor: Sandra Babić (mentor)
• Committee member: Sandra Babić (predsjednik povjerenstva)
• Committee member: Dragana Mutavdžić Pavlović (član povjerenstva)
• Committee member: Lidija Furač (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2020-09-14, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Cilj ovoga rada bio je proučiti hidrolitičku razgradnju norfloksacina u okolišu. Proizvodnja i potrošnja farmaceutika sve više raste čime je njihova koncentracija u okolišu sve veća. Kada farmaceutik dođe u okoliš izložen je različitim čimbenicima iz okoliša koji mogu dovesti do njegove razgradnje prilikom čega mogu nastati toksični razgradni produkti. Iz tog razloga je veoma bitno promatrati razgradnju farmaceutika u okolišu. Na samom početku potrebno je utvrditi kako farmaceutici dolaze u okoliš i koji su mogući putevi njihove razgradnje u okolišu što je navedeno u općem djelu rada. Nakon toga slijedi pregled literature u kojem su opisani radovi u kojima je istražena hidrolitička razgradnja norfloksacina i drugih farmaceutika. Svaki članak proučava hidrolitičku razgradnju različitih farmaceutika uz različite eksperimentalne uvjete, primjenu različitih kromatografskih metoda za praćenje razgradnje te različitih načina detekcije.

Abstract (english)

This thesis aimed to study hydrolytic degradation of norfloxacin in the environment. Production and consumption of pharmaceuticals is growing more and more whereby their concentration in the environment is bigger. When pharmaceuticals come in the environment they are exposed to different environmental factors which can lead to their degradation and results with toxic degradation products. Because of that, it is very important to monitor the degradation of pharmaceuticals in the environment. In the beginning it is needed to determine pharmaceutical pathways into the environment and possible ways of their degradation in the environment, which is stated in the general part in this thesis. After that, review of the literature investigating hydrolytic degradation of norfloxacin and other pharmaceuticals is presented. Each article study hydrolytic degradation of different pharmaceuticals with different experimental conditions, using different chromatographic methods for monitoring the degradation and different detection.

• Keywords: hidrolitička razgradnja; farmaceutik; norfloksacin; razgradni produkti; okoliš; kromatografija
• Keywords (english): hydrolytic degradation; pharmaceutical; norfloxacin; degradation products; environment; chromatography
• Language: croatian
• URN:NBN: urn:nbn:hr:149:524364
• Study programme: Title: Applied Chemistry - Graduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Applied organic chemistry; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra primijenjene kemije (magistar/magistra primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-03-02 15:04:33