Određivanje optimalnih uvjeta razgradnje farmaceutika u vodi naprednim oksidacijskim procesima

master's thesis

• Title (english): AOP degradation of pharmaceuticals in water: determination of optimal conditions
• Author: Ana Tolić
• Mentor: Šime Ukić (mentor)
• Committee member: Šime Ukić (predsjednik povjerenstva)
• Committee member: Matija Cvetnić (član povjerenstva)
• Committee member: Lidija Furač (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2020-09-29, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Farmaceutici su sintetski proizvodi neizostavni u svakodnevnoj upotrebi. Smatra se da je trenutno u uporabi oko 3000 farmaceutski aktivnih supstanci, a procjenjuje se da će do 2023. više od 50 novih farmaceutika doći na tržište. Stoga, njihov unos time i akumulacija u okolišu raste što može imati negativne posljedice na cjelokupni ekosustav. U ovom radu istražena je razgradnja 4 različita farmaceutika: desvenlafaksina, donepezil hidroklorida, hidroklortiazida i omeprazola naprednim oksidacijskim procesima fotooksidacije, UV/H2O2 i UV/PS. U svrhu procjene utjecaja procesnih parametara (pH, koncentracija oksidansa i vrsta radikala) na razgradnju farmaceutika korištenjem metode površine odziva razvijeni su modeli. Statističkom analizom utvrđeno je da su razvijeni modeli značajni i točni. Modeli zadovoljavaju kriterije R^2 > 0,9, R^2adj > 0,9 p < 0,05. Razgradnja istraženih farmaceutika kinetici prvog reda bez obzira na strukturne razlike kroz čitav niz ispitivanih parametara procesa. Rezultati su ukazali da je kinetika razgradnje desvenlafaksina, donepezil hidroklorida te hidroklortiazida veća u UV/PS nego u UV/H2O2 procesu. Vrijednosti kinetike degradacije omeprazola UV/H2O2 procesom veće su od kinetike UV/PS procesa.

Abstract (english)

Pharmaceuticals are indispensable components in everyday use and their use is constantly growing. Approximately 3000 pharmaceutically active substances are currently in use and it has been estimated that by 2023, more than 50 new pharmaceuticals will be on the market. Consequently, their accumulation and quantity in the environment increases which can have negative consequences on the whole ecosystem. In this study, the degradations of 4 different pharmaceuticals (desvenlafaxine, donepezil hydrochloride, hydrochlorothiazide and omeprazole) by photooxidation, UV/H2O2 and UV/PS processes were observed. The influences of process parameters (pH, oxidant concentration and type of radical) on the degradation were studied using the response surface methodology. Statistical analysis showed that the developed models are significant and accurate. The models meet the criteria R^2 > 0.9, R^2adj > 0.9 p < 0.05. It was found that the degradation obeys the first order kinetics regardless of the structural differences throughout the examined process parameters. The results indicated that degradation kinetics of desvenlafaxine, donepezil hydrochloride and hydrochlorothiazide were higher in case of UV/PS process than in case UV/H2O2 process. The degradation kinetics of the omeprazole UV/H2O2 process was higher than the kinetics of the UV/PS process.

• Keywords: farmaceutici; fotooksidacija; UV/H2O2; UV/PS
• Keywords (english): pharmaceuticals; photooxidation; UV/H2O2; UV/PS
• Language: croatian
• URN:NBN: urn:nbn:hr:149:541902
• Project: Number: IP-2014-09-7992; Title: Modeliranje okolišnih aspekata napredne obrade voda za razgradnju prioritetnih onečišćivala; Title: Modeling of environmental aspects of advanced water treatment for fegradation of priority pollutants; Acronym: MEAoWT; Leader: Tomislav Bolanča; Jurisdiction: Croatia; Funder: HRZZ; Funding stream: IP
• Study programme: Title: Applied Chemistry - Graduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Environmental chemistry and green technologies; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra primijenjene kemije (magistar/magistra primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-04-20 12:19:44