Evaluation of water matrix effect on degradation of pharmaceuticals and determination of degradation mechanism

master's thesis

• Title (croatian): Procjena utjecaja vodene matrice na razgradnju farmaceutika i određivanje mehanizma razgradnje
• Author: Amin Samzadeh
• Mentor: Tomislav Bolanča (mentor)
• Committee member: Tomislav Bolanča (predsjednik povjerenstva)
• Committee member: Hrvoje Kušić (član povjerenstva)
• Committee member: Ana Lončarić Božić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Granter: University of Split; Faculty of Chemistry and Technology; Split
• Defense date and country: 2021-06-25, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

According to the 3rd EU Watch List under the Water Framework Directive, a list of substances was suggested as good candidates for the next watchlist. In this study two pharmaceuticals from this list were chosen, Carbamazepine (CBZ) and Ibuprofen (IBP), two important and widely used recalcitrant pharmaceuticals found in water. The aim of this study is to evaluate the influence of several water matrix factors on the degradation of CBZ and IBP, with three different advanced oxidation processes (AOPs). To the best of our knowledge so far, there has been no research comparing UV-C, ultrasound (US) and microwave (MW) based processes under different operational parameters (oxidant dosage, pH, humic acid, nitrite ion, nitrate ion, chloride ion, phosphate ion and sulfate ion). Each of these factors depend on the degradation process had synergistic or inhibitory effect on degradation rate of studied pharmaceuticals. The used Taguchi method had great and significant results and indicated the effect of studied factors on degradation processes that, in most cases, were in agreement with previous literature findings, as well as required fewer experiments, time, and costs. Water matrix constituents had a significant impact on the degradation efficiency. Furthermore, the biodegradability of CBZ and IBP and degradation products of CBZ through UV-C based processes were investigated.

Abstract (croatian)

Prema 3. popisu prioritetnih tvari prema Okvirnoj direktivi o vodama EU, popis tvari koje treba pratiti predložen je kao dobar kandidat za sljedeći popis prioritetnih tvari. U ovom radu odabrana su dva farmaceutika s ovog popisa, karbamazepin (CBZ) i ibuprofen (IBP), dva važna i široko korištena rekalcitratna farmaceutika pronađena u vodi. Cilj ovog istraživanja je procijeniti utjecaj nekoliko čimbenika vodene matrice na razgradnju CBZ i IBP, s tri različita napredna oksidacijska procesa (AOP). Koliko nam je poznato, do sada nije bilo istraživanja koja bi uspoređivala procese temeljene na UV-C, ultrazvuku (US) i mikrovalovima (MW) pod različitim radnim parametrima (doza oksidansa, pH, huminska kiselina, nitritni ion, nitratni ion, klorid ion, fosfatni ion i sulfatni ion). Svaki od ovih čimbenika, ovisno o procesu razgradnje, imao je sinergistički ili inhibitorni učinak na brzinu razgradnje ispitivanih farmaceutika. Korištena Taguchi metoda dala je izvrsne i značajne rezultate te je ukazala na utjecaj proučavanih čimbenika na procese razgradnje koji su u većini slučajeva bili u skladu s dosadašnjim literaturnim nalazima, te su zahtijevali manje eksperimenata, vremena i troškova. Sastojci vodene matrice imali su značajan utjecaj na učinkovitost razgradnje. Nadalje, ispitana je biorazgradivost CBZ-a i IBP-a i produkti razgradnje CBZ-a putem UV-C procesa.

• Keywords: UV-C-based processes; ultrasound-based processes; microwave-based processes; Carbamazepine; Ibuprofen; water matrix
• Keywords (croatian): procesi temeljeni na UV-C; procesi temeljeni na ultrazvuku; procesi temeljeni na mikrovalovima; karbamazepin; ibuprofen; vodena matrica
• Language: english
• URN:NBN: urn:nbn:hr:149:140589
• Study programme: Title: Chemical and environmental technology - graduate - university; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2022-06-30
• Created on: 2023-04-21 13:32:40