Određivanje topljivosti i karakterizacija djelatne tvari

undergraduate thesis

• Title (english): Determination of solubility and characterization of the active pharmaceutical ingredient
• Author: Bianca Lerotić
• Mentor: Jasna Prlić Kardum (mentor)
• Committee member: Jasna Prlić Kardum (predsjednik povjerenstva)
• Committee member: Aleksandra Sander (član povjerenstva)
• Committee member: Lidija Furač (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2023-09-08, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Farmaceutska industrija je danas jedna od najrazvijenijih industrija. Podaci o topljivosti djelatne tvari i kemijskih međuproizvoda koji se koriste u farmaceutskoj industriji osnovni su podatci koji su potrebni za proces sinteze i pročišćavanja. Osim toga, s gotovo 40% spojeva koji se koriste kao lijekovi imaju problem s topljivosti. Stoga je svaki pokušaj predviđanja topljivosti vrlo važan u istraživanjima otkrivanja lijekova. U radu je određena topljivost dviju djelatnih tvari, dronedaron hidroklorida i ceritiniba u različitim otapalima i smjesama otapala. Dobiveni eksperimentalni podaci (dronedaron hidroklorid i ceritinib) te literaturni podaci (dronedaron hidroklorid) korelirani su različitim jednadžbama kao što su modificirana Apelblatova, Yawsova i Van’t Hoffova jednadžba. Sve jednadžbe dobro opisuju dobivene podatke, a bolje slganje esperimentalnih i računski određenih podataka ovisi o komponenti čija se topljivost određuje, rasponu ispitivanog temperaturnog područja, otapalu te eksperimentalnoj metodi.

Abstract (english)

Today, the pharmaceutical industry is among the most advanced industries. Data on the solubility of the active substance and chemical intermediates used in the pharmaceutical industry are the fundamental data required for the synthesis and purification process. In addition, nearly forty percent of pharmaceutical compounds have solubility issues. Consequently, any attempt to predict solubility is crucial to drug discovery research. This study determined the solubility of two active substances, dronedarone hydrochloride and ceritinib, in various solvents and solvent mixtures. This study examined the solubility of two active compounds, ceritinib and dronedarone hydrochloride, in various solvents and solvent combinations. Dronedarone hydrochloride and ceritinib obtained from the experiments and Dronedarone hydrochloride from the literature were correlated using a variety of equations, including the modified Apelblat, Yaws, and Van't Hoff equations. The better agreement between experimental and computationally calculated data depends on the component whose solubility is determined, the range of the tested temperature range, the solvent, and the experimental method. All equations adequately describe the given data.

• Keywords: Apelblatova jednadžba; ceritinib; dronedaron hidroklorid; topljivost; Van’t Hoffova jednadžba; Yawsova jednadžba
• Keywords (english): Apelblat equation; ceritinib; dronedarone hydrochloride; solubility; Van't Hoff equation; Yaws equation
• Language: croatian
• URN:NBN: urn:nbn:hr:149:358476
• Project: Number: KK.01.1.1.07.0017; Title: Napredno vođenje procesa kristalizacije; Title: Advanced Control of Crystallization Process; Acronym: CrystAPC; Leader: Nenad Bolf; Jurisdiction: Croatia; Funder: EK; Funding stream: EFRR
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-09-12 13:38:01