Biološka aktivnost bioaktivnih stakala u području inženjerstva tkiva

undergraduate thesis

• Title (english): Biological activity of bioactive glasses in the field of tissue engineering
• Author: Anamaria Martinović
• Mentor: Anamarija Rogina (mentor)
• Committee member: Anamarija Rogina (predsjednik povjerenstva)
• Committee member: Dajana Milovac Lerga (član povjerenstva)
• Committee member: Leonard Bauer (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2023-09-21, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Inženjerstvo koštanog tkiva interdisciplinarno je područje koje razvija materijale i metode za liječenje, popravljanje i zamjenu oštećenog koštanog tkiva. Bioaktivno staklo je materijal koji pokazuje odlična svojstva za primjenu u inženjerstvu koštanog tkiva. Bioaktivnost, osteoinduktivnost i osteoproduktivnost svojstva su koja mu omogućuju stvaranje direktne veze s tkivom. Reakcijom bioaktivnog stakla u fiziološkom okruženju dolazi do razgradnje stakla i otpuštanja iona koji potiču okoštavanje i aktiviraju bitne gene. Optimiranjem karakteristika bioaktivnog stakla poput sastava, mikrostrukture i makrostrukture može se značajno utjecati na bioaktivna svojstva materijala. Posebice je zanimljiva raznolikost u sastavu što se tiče odabira kemijskih elemenata, udjela i koncentracija pojedinih komponenata, koji se pažljivo optimiraju kako bi se postigla željena svojstva. Ovim završnim radom dan je uvid u strukturu i svojstva bioaktivnih stakala koja se primjenjuju u području inženjerstva koštanog tkiva, a osobito onih koja imaju najvažniju ulogu u stvaranju direktne veze s koštanim tkivom.

Abstract (english)

Bone tissue engineering is an interdisciplinary field that develops methods to treat, repair, and replace damaged bone tissue. Bioactive glass is a material that shows excellent properties for use in bone tissue engineering. Bioactivity, osteoinductivity and osteoconductivity are properties that enable it to form a direct bond with the tissue.
The reaction of bioactive glass in a physiological environment leads to the degradation of glass and the release of ions that promote ossification and activate relevant genes.
By optimizing the characteristics of bioactive glass, such as composition, microstructure and macrostructure, the bioactive properties can be significantly influenced. The variety in the composition is particularly interesting as regards the selection of chemical elements, the ratio and concentration of individual components, which are carefully optimized in order to achieve the desired properties. This paper provides insight into the structure and properties of bioactive glasses that are used in the field of bone tissue engineering, especially those that play the most important role in creating a direct bond with bone tissue.

• Keywords: inženjerstvo tkiva; bioaktivna stakla; bioaktivnost
• Keywords (english): tissue engineering; bioactive glasses; bioactivity
• Language: croatian
• URN:NBN: urn:nbn:hr:149:620976
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2024-01-01
• Created on: 2023-11-29 16:29:08