Fotokatalitička razgradnja albendazola

master's thesis

• Title (english): Photocatalytic degradation of albendazole
• Author: Katarina Vrbat
• Mentor: Sandra Babić (mentor)
• Committee member: Sandra Babić (predsjednik povjerenstva)
• Committee member: Mirta Čizmić (član povjerenstva)
• Committee member: Dragana Vuk (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2016-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry; Analytic Chemistry

Abstract

U ovom radu ispitana je fotolitička i fotokatalitička razgradnja antihelmintika albendazola. Osim direktne fotolize provedeni su oksidacijski procesi koji su uključivali UV/TiO2 i UV/H2O2 u kojima je korišteno UV-A i UV-C zračenje. Razgradnja albendazola praćena je tekućinskom kromatografijom visoke djelotvornosti, a uz mehanizam razgradnje određena je i kinetika reakcije razgradnje. Tijekom svih ispitivanih procesa uočeno je smanjenje koncentracije albendazola. Dodatak ozona i oksidansa, H2O2, ubrzao je fotolitičku i fotokatalitičku razgradnju ispitivanog farmaceutika. Fotokatalizator TiO2 nanesen u obliku tankog filma ubrzao je razgradnju albendazola. Određena je kinetika fotolitičke i fotokatalitičke razgradnje albendazola, koja je složena i može se podijeliti u dva područja te u svakom od njih slijedi kinetiku prvog reda. Razgradnja je u svim slučajevima brža na početku, a sporija u drugom području. Određen je utjecaj slobodnih radikala na mehanizam fotokatalitičke razgradnje te je ustvrđeno da hidroksilni radikal ima značajnu ulogu u fotokatalitičkoj razgradnji albendazola uz UV-A zračenje, a singletni kisik te superoksidni radikal ne utječu na fotokatalitičku razgradnju. Detektirana su dva razgradna produkta koji su identificirani kao albendazol sulfoksid i albendazol sulfon, metaboliti albendazola.

Abstract (english)

In this work photolytic and photocatalytic degradation of anthelmintic albendazole were investigated. Besides the direct photolysis, oxidation processes including UV/TiO2 and UV/H2O2 using UV-A and UV-C radiation were investigated. The degradation of albendazole was monitored using high performance liquid cromatography. The mechanism of albendazole degradation and degradation kinetics were determined. In all investigated processes concentration of albendazole were decreased. The addition of ozone and oxidant, H2O2, accelerated the photolytic and photocatalytic degradation of albendazole. In the photocatalytic degradation, using TiO2 film as catalyst, faster degradation was observed. The kinetics of photolytic and photocatalytic degradation of albendazole is complex and can be divided in two areas. In both of them degradation rate of albendazole can be described by the first-order kinetics. In all cases degradation was faster at the beginning of degradation process and slower in the second area. The effect of three radicals were investigated and it can be concluded that hydroxyl radical has an important role in photocatalytic degradation with UV-A radiation. The singlet oxygen and super oxide radical has no affect on photocatalytic degradation. Two degradation products were detected and identified based as albendazole sulfoxide i albendazol sulone, metabolites of albendazole.

• Keywords: farmaceutici; albendazol; fotolitička razgradnja; fotokatalitička razgradnja; titan dioksid film; kinetika razgradnje; mehanizam razgradnje
• Keywords (english): pharmaceuticals; albendazole; photolytic degradation; photocatalytic degradation; titanium dioxide film; degradation kinetics; degradation mechanism
• Language: croatian
• URN:NBN: urn:nbn:hr:149:256871
• Study programme: Title: Materials Science and Engineering - Graduate study; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-07-04 12:27:15