Sorpcija sulfametoksazola - usporedba polimera s otiskom molekule sulfametoksazola i polimera bez otiska

undergraduate thesis

• Title (english): Sorption of sulfamethoxazole - sulfametoxazole imprinted polymer vs. non-imprinted polymer
• Author: Ivana Čolo
• Mentor: Dragana Mutavdžić Pavlović (mentor)
• Committee member: Dragana Mutavdžić Pavlović (predsjednik povjerenstva)
• Committee member: Kristina Tolić Čop (član povjerenstva)
• Committee member: Ivana Sokol (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2024-09-12, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Sulfametoksazol je sulfonamidni antibiotik koji se najčešće koristi u humanoj medicini. Neučinkovito uklanjanje sulfametoksazola iz otpadnih voda tijekom postupaka obrade otpadnih voda, dovodi do njegove povećane prisutnosti u okolišu što može izazvati štetne učinke na okoliš, zdravlje ljudi i životinja. Jedan od najvažnijih procesa za uklanjanje farmaceutika iz okoliša je sorpcija. Stoga je u ovome radu ispitana sorpcija sulfametoksazola na polimeru sa i bez otiska molekule sulfametoksazola i utjecaj pH, temperature, ionske jakosti, mase sorbensa i matrice otpadne vode. Na temelju koeficijenata determinacije
(R^2 > 0,9999) i odličnog slaganja qe,exp s qe,calc, kinetiku sorpcije na oba sorbensa najbolje opisuje pseudokinetički model 2. reda. Za opis sorpcije pri svim navedenim uvjetima korištene su linearna, Freundlichova i Langmuirova izoterma, a rezultati pokazuju najbolje slaganje sa lineranim oblikom izoterme (R^2 > 0,99 za NIP, R^2 > 0,99 za MIP osim u tri slučaja gdje R^2 > 0,98). Vrijednost koeficijenta raspodjele (Kd) je pri svim ispitivanim utjecajima znatno veći za MIP nego za NIP što ukazuje na veći afinitet sorpcije sulfametoksazola na MIP-u. Također, dobivene vrijednosti faktora utiskivanja ukazuju na uspješno molekularno utiskivanje i veću sposobnost MIP-a za sorpciju sulfametoksazola u odnosu na NIP.

Abstract (english)

Sulfamethoxazole is a sulfonamide antibiotic that is most commonly used in human medicine. The inefficient removal of sulfamethoxazole from wastewater during wastewater treatment leads to its increased presence in the environment, which can have a negative impact on the environment and human and animal health. One of the most important processes for the removal of pharmaceuticals from the environment is sorption. Therefore, the sorption of sulfamethoxazole on sulfamethoxazole-imprinted polymer and non-imprinted polymer and the influence of pH, temperature, ionic strength, sorbent mass and wastewater matrix were investigated in this work. Due to the coefficients of determination (R^2 > 0.9999) and the excellent agreement between qe,exp and qe,calc, the sorption kinetics on both sorbents are best described by the second-order pseudokinetic model. Linear, Freundlich and Langmuir isotherms were used to describe sorption under all conditions mentioned, and the results show the best compatibility with the linear form of the isotherm (R^2 > 0.99 for NIP, R^2 > 0.99 for MIP except in three cases where R^2 > 0.98). The partition coefficient (Kd) for all tested effects is significantly higher for MIP than for NIP, indicating a higher sorption affinity of sulfamethoxazole to MIP. The values obtained for the imprinting factor also indicate a successful molecular imprinting and a greater ability of MIP to sorb sulfamethoxazole compared to NIP.

• Keywords: sulfametoksazol; sorpcija; polimer s otiskom molekule sulfametoksazola; koeficijent raspodjele
• Keywords (english): sulfamethoxazole; sorption; sulfamethoxazole-imprinted polymer; partition coefficient
• Language: croatian
• URN:NBN: urn:nbn:hr:149:137364
• Project: Number: IP-2022-10-4400; Title: Razvoj polimera s otiskom molekula za primjenu u analizi farmaceutika i tijekom naprednih postupaka obrade voda; Title: Development of molecularly imprinted polymers for use in analysis of pharmaceuticals and during advanced water treatment processes; Acronym: MIPdePharma; Leader: Dragana Mutavdžić Pavlović; Jurisdiction: Croatia; Funder: Hrvatska zaklada za znanost; Funding stream: Research Projects
• Study programme: Title: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Environmental chemistry and green technologies; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2025-09-30
• Created on: 2024-11-14 13:03:43