Sinteza i karakterizacija cijepljenog kopolimera derivata celuloze i dibutil maleata

undergraduate thesis

• Title (english): Synthesis and characterisation of a cellulose derivative and dibutyl maleate graft copolymer
• Author: Vedran Kovačević
• Mentor: Fabio Faraguna (mentor)
• Committee member: Fabio Faraguna (predsjednik povjerenstva)
• Committee member: Elvira Vidović (član povjerenstva)
• Committee member: Marin Kovačić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2024-09-12, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Celuloza je zastupljen polisaharid u prirodnom svijetu. Nalazi se u staničnim stijenkama biljaka, a može se dobiti i iz drugih izvora poput bakterija. Iz tog je razloga ona, kao sirovina, vrlo pristupačna. Zbog svoje biokompatibilnosti vrlo je zastupljena u farmaceutskoj industriji za svrhe poput dostave lijekova unutar organizma. Zbog jakih intermolekularnih interakcija, celuloza nije topiva u većini otapala, što u farmaceutskoj industriji nije poželjno. Iz tog razloga se često koriste njeni derivati gdje su hidroksilne skupine zamijenjene drugim funkcionalnim skupinama. U ovom se radu provodila cijepljena kopolimerizacija natrij karboksimetil celuloze dibutil maleatom uz inicijator cerij (IV) amonijev nitrat te cijepljena kopolimerizacija (hidroksipropil)metil celuloze s kopolimerom maleinskog anhidrida i dibutil maleata uz inicijator azobisizobutironitril. Svrha ovog rada bila je sinteza cijepljenih kopolimera radi njihove potencijalne primjene kao stabilizatorima aktivnih farmaceutskih sastojaka. Dobiveni produkti su karakterizirani diferencijalnom pretražnom kalorimetrijom, termogravimetrijskom analizom i infracrvenom spektroskopijom s Fourierovim transformacijama.
Uspješno je sintetiziran kopolimer natrij karboksimetil celuloza-graft-poli(dibutil maleat) (NaCMC-g-DiBuMal), ali uz nisko iskorištenje reakcije od 3%.

Abstract (english)

Cellulose is a abundant polysaccharide nature. It is found in the cell walls of plants and can also be obtained from other sources like bacteria, making it an easily accessible raw material. Due to its biocompatibility, cellulose is widely used in the pharmaceutical industry for applications such as drug delivery. However, because of its strong intermolecular interactions, cellulose is not soluble in most solvents, which is undesirable in pharmaceutical applications. To address this issue, derivatives of cellulose are often used, where the hydroxyl groups are replaced with other functional groups. In this study, graft copolymerization of sodium carboxymethyl cellulose (NaCMC) with dibutyl maleate was conducted using cerium (IV) ammonium nitrate as the initiator. Additionally, graft copolymerization of (hydroxypropyl)methyl cellulose with a copolymer of maleic anhydride and dibutyl maleate was carried out using azobisisobutyronitrile as the initiator. The purpose of this study was to synthesize graft copolymers for their potential application as stabilizers of active pharmaceutical ingredients. The products obtained were characterized using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and
Fourier-transform infrared spectroscopy (FTIR). The copolymer sodium carboxymethyl cellulose-graft-poly(dibutyl maleate) (NaCMC-g-DiBuMal) was successfully synthesized, butSwith a reaction yield of 3% while the syntesis using HPMC yielded no result.

• Keywords: cijepljena kopolimerizacija; natrij karboksimetil celuloza; (hidroksipropil)metil celuloza; dibutil maleat; stabilizator aktivnih farmaceutskih sastojaka
• Keywords (english): graft copolymerization; sodium carboxymethyl cellulose; (hydroxypropyl)methyl cellulose; dibutyl maleate; stabilizer for active pharmaceutical ingredients
• Language: croatian
• URN:NBN: urn:nbn:hr:149:151482
• Project: Number: NPOO.C3.2.R3-I1.04.0126; Title: Razvoj i karakterizacija kompleksnih sustava za isporuku lijeka s produljenim oslobađanjem naosnovi biorazgradivih polimera; Title: Development and characterization of complex prolonged release drug delivery systems based on biodegradable polymers; Acronym: InINJECT; Leader: Fabio Faraguna; Jurisdiction: eu; Funder: Europska unija
• Study programme: Title: Materials Science and Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2027-01-01
• Created on: 2024-11-14 13:39:58