Mehanokemija: zeleni pristup u pripravi farmaceutskih proizvoda poboljšanih svojstava

undergraduate thesis

• Title (english): Mechanochemistry: a green approach in preparation of pharmaceutical products with improved properties
• Author: Adrijana Karniš
• Mentor: Krunoslav Žižek (mentor)
• Committee member: Krunoslav Žižek (predsjednik povjerenstva)
• Committee member: Jelena Macan (član povjerenstva)
• Committee member: Petar Kassal (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2024-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Izazovi današnjice zahtijevaju sve veću brigu za okoliš, stoga se i farmaceutska industrija susreće s novim izazovima u održivoj proizvodnji. Nekoć su farmaceutska istraživanja bila fokusirana na otkrivanje novih djelatnih tvari, dok su danas mnoga orijentirana k poboljšanju svojstva već postojećh lijekova. Dodatni izazov je razvoj novog procesa proizvodnje koji slijedi načela zelene kemije kako bi se što manje utjecalo na okoliš i razvila održiva proizvodnja. Rješenje ovih izazova nam daje mehanokemija. Za mehanokemijsku pripravu čvrstih disperzija u mlinovima nisu potrebna otapala te je moguće ovim “zelenim pristupom” proizvesti lijek poboljšanih svojstava.

Abstract (english)

Care for the environment is more important than ever, which is why the pharmaceutical industry is facing new challenges in terms of sustainable production. Once, pharmaceutical research was focused on the discovery of new drugs, while today is oriented mainly on improving the properties of already existing drug products. Development of new production processes that follows the principles of green chemistry to minimise the environmental impact and develop sustainable production is a completely new challenge. Mechanochemistry offers a solution to those challenges. No solvents are needed for mechanochemical preparation of solid dispersions in mills, and it is possible using this “green approach” to produce drug product with improved properties.

• Keywords: mehanokemija; zelena kemija; čvrsta disperzija; lijek poboljšanih svojstava
• Keywords (english): mechanochemistry; green chemistry; solid dispersion; drug with improved properties
• Language: croatian
• URN:NBN: urn:nbn:hr:149:569139
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-11-17 10:21:04