Utjecaj tipa oksidansa na razgradnju memantina

undergraduate thesis

• Title (english): The effect of oxidant type on the degradation of memantine
• Author: Lucija Štajduhar
• Mentor: Hrvoje Kušić (mentor)
• Committee member: Hrvoje Kušić (predsjednik povjerenstva)
• Committee member: Ana Lončarić Božić (član povjerenstva)
• Committee member: Šime Ukić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2018-09-12, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering; Environmental Protection in Chemical Engineering

Abstract

U današnje vrijeme sve veća upotreba farmaceutika postaje problem zaštite okoliša te se stoga povećava interes o informacijama o njihovoj prisutnosti u okolišu kao i o njihovim mogućim štetnim utjecajima na okoliš. Farmaceutici se u okoliš unose kontinuirano pri niskim koncentracijama, ali to ne znači da rizik ne postoji, jer farmaceutici su dizajnirani da izazivaju biološke učinke upravo pri vrlo niskim dozama. Lijekovi, njihovi metaboliti i proizvodi transformacija detektiraju se u otpadnim vodama, površinskim vodama, morima i tlu. Memantin je jedan od brojnih lijekova koji su detektirani u vodenom okolišu te predstavljaju potencijalan negativan utjecaj na ljudsko zdravlje i okoliš. To je relativno novi lijek na tržištu koji se koristi za liječenje bolesnika s umjerenom ili teškom Alzheimerovom bolesti. U ovome radu ispitana je učinkovitost razgradnje memantina uz peroctenu kiselinu (PAA) bez dodatka katalizatora te s dodatkom katalizatora. Peroctena kiselina je dezinficijens visokog stupnja djelotvornosti. Jako je oksidacijsko sredstvo koje stvara netoksične razgradne produkte, a uz to brzo reagira, stabilna je i sigurna te je stoga upotreba peroctene kiseline ekološki prihvatljiva. Ispitana je i mogućnost razgradnje memantina peroctenom kiselinom uz željezov (II) sulfat kao homogeni katalizator za ubrzanje razgradnje memantina, analogno Fentonovom procesu. Korišten je puni faktorski eksperimentalni plan, pri čemu varijable predstavljaju koncentracije Fe2+ i PAA, dok je pH zadan kao kategorički faktor. Katalitička razgradnja memantina pokazala se znatno bržom te su određeni optimalni uvjeti za razgradnju memantina procesom PAA/Fe2+, koji iznose [Fe2+]= 50 mg L^-1 te [PAA] = 5 mM.

Abstract (english)

Nowadays, the increasing use of pharmaceuticals is becoming a new environmental concern. Therefore, the interest in having information about their presence in the environment and their possible adverse effects to the environment is considerably increasing. Pharmaceuticals are continuously entering the environment, although in small concentrations, the risk is still there because pharmaceuticals are designed to cause biological impact just under the very low dosage. Drugs, metabolites and transformation products are detected in receiving waters, surface waters, seas and soil. Memantine is one of the numerous drugs detected in aquatic environment that represent potentially negative impact for human health and environment. It is a relatively newly registered drug which has been used in the treatment of patients with moderate to severe Alzheimer’s disease. In this work the efficiency of memantine degradation with peracetic acid without and with the addition of a catalyst was investigated. Peracetic acid (PAA) is a disinfectant with a high degree of efficiency. It has strong oxidizing properties, reacts quickly and produces nontoxic decomposition products. PAA is stable and safe, so its use is ecologically acceptable. Degradation of memantine with peracetic acid with or without iron (II) sulfate as a homogenous catalyst was tested, akin to the Fenton process. Full factorial experimental design was used, in which variables represent concentrations of Fe2+ and PAA, while pH was set as a categorical factor. Catalyzed degradation of memantine has achieved the highest degradation rate, optimal conditions for the process PAA/Fe2+ were found to be [Fe2+]= 50 mg L^-1 and [PAA] = 5 mM.

• Keywords: farmaceutici; memantin; peroctena kiselina; Fentonu sličan proces; statističko planiranje eksperimenata
• Keywords (english): pharmaceuticals; memantine; peracetic acid; modified Fenton-like process; statistical experimental design
• Language: croatian
• URN:NBN: urn:nbn:hr:149:439907
• Study programme: Title: Environmental Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Closed access
• Created on: 2021-11-22 11:57:18