Razgradnja memantina u vodi UVC/H2O2 i UVA-TiO2 procesima

master's thesis

• Title (english): Degradation of memantine in water by UVC/H2O2 and UVA-TiO2 processes
• Author: Stefani Majdandžić
• Mentor: Ana Lončarić Božić (mentor)
• Committee member: Ana Lončarić Božić (predsjednik povjerenstva)
• Committee member: Marin Kovačić (član povjerenstva)
• Committee member: Matija Cvetnić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2020-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Pravilnim metodama praćenja stanja i metodama analiza utvrđuje se stanje vodenih ekosustava tj. okoliša u cijelosti, a u posljednje se vrijeme ubrzano radi na metodama praćenja stanja, analiza te uklanjanja tzv. novih onečišćivala iz voda. Vrlo važna skupina novih onečišćivala jesu i farmaceutici koji se nalaze na listi prioritetnih tvari, a za koje još nema validiranih, univerzalnih metoda praćenja te uklanjanja. Memantin, MEM, je farmaceutik koji se primjenjuje za liječenje Alzheimerove bolesti, a nakon primjene dospijeva i u vode (u koncentracijama 10 do 100 ng/L) gdje se dugo zadržava i teško uklanja klasičnim metodama obrade otpadnih voda. Brojne su prednosti naprednih oksidacijskih procesa zbog kojih se često razmatraju upravo za uklanjanje različitih onečišćujućih tvari (uključujući i farmaceutike) iz otpadnih voda. U ovom je radu ispitana mogućnosti primjene dva napredna oksidacijska procesa: fotooksidacije, UV-C / H2O2 te heterotrofne fotokatalize UV-A / TiO2 za razgradnju farmaceutika memantina, MEM. U šaržnom reaktoru, u uvjetima kontrolirane temperature, ispitan je utjecaj pH i koncentracije vodikovog peroksida, H2O2, i titanijevog dioksida, TiO2, na učinkovitost uklanjanja farmaceutika MEM-a te je razvijen matematički model kojim su promatrani procesi opisani. Procesi su praćeni visoko učinkovitom tekućinskom kromatografijom (HPLC), a zbog svojstava MEM-a prije analize proveden je postupak derivatizacije uzoraka. Pri optimalnim uvjetima određena je i kemijska potrošnja kisika (KPK) i biokemijska potrošnja kisika (BPK5). Optimalni uvjeti pri fotooksidaciji su pH = 6,97 i [H2O2]=15,21 mM uz kinetičku konstantu 0,0307 s^-1, a pri fotokatalizi su pH = 4 i γ(TiO2) = 0,955 g/L te uz kinetičku konstantu 0,326 s^-1.U slučaju fotooksidacije utjecaj vodene matrice je inhibirajući, a u slučaju fotokatalize promovirajući. Biorazgradivost uzoraka raste povećanjem mineralizacije MEM-a.

Abstract (english)

To establish water quality as quality of environment it is necessary to have validated and universal monitoring, analysis and removal methods which is lately one of the main golds of many scientists, primarly for new emerging pollutants such as pharmaceuticals. Memantine, MEM, is pharmaceutical that's often used for Alzheimer's disease treatment. After use this pharmaceutical reaches waters (concentrations of 10 to 100 ng/L) where it is retained for a long time and conventional wastewater treatment methods are ineffective for removal od MEM. There are many advantages of advanced oxidation processes, that are making them suitable for removal of different pollutants (pharmaceuticals). In this research the possibility of applying two advanced oxidation processes: photooxidation, UV-C/H2O2, and heterogeneous photocatalysis, UV-A/TiO2, for removal of pharmaceutical memantine, MEM, was examined. Influence of two parameters: pH and concentraction of hydrogen peroxide, H2O2, and titanium dioxide, TiO2, on removal efficiency of MEM was monitored with contorled temeprature conditions in a batch reactor. Also, to describe these two processes, mathematical model was developed. Processes are monitored by high performance liquid chromatography (HPLC) and samples are derivatized because of the specific MEM structure. Chemical oxygen demand (COD) and biochemical oxygen demand (BOD). Optimal conditions in photooxidation are: pH = 6,97 and [H2O2]=15,21 mM, with kinetic constant 0,0307 s^-1 and in photocatalysis are pH = 4 i γ(TiO2) = 0,955 g/L with kinetic constant 0,326 s^-1. Water matrix has inhibitory effect on photooxidation, and promoting effect on photocatalysis. Biodegradation of samples increases along with increase of mineralization of MEM.

• Keywords: obrada otpadnih voda; farmaceutici; memantin; napredni oksidacijski procesi
• Keywords (english): wastewater treatment; pharmaceuticals; memantine; advanced oxidation processes
• Language: croatian
• URN:NBN: urn:nbn:hr:149:575491
• Study programme: Title: Environmental Engineering - Graduate study; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka ekoinženjerstva (magistar/magistra inženjer/inženjerka ekoinženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Closed access
• Created on: 2022-03-06 13:19:59