Polimeri za dostavu lijeka s kontroliranim oslobađanjem

undergraduate thesis

• Title (english): Polymers for drug delivery applications
• Author: Benjamin Banožić
• Mentor: Ante Jukić (mentor)
• Committee member: Ante Jukić (predsjednik povjerenstva)
• Committee member: Fabio Faraguna (član povjerenstva)
• Committee member: Mirela Leskovac (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2019-09-13, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

U ovom radu provedena je sinteza i karakterizacija kopolimera za oblikovanje farmaceutskih proizvoda. Sintetizirano je sedam kopolimera metil-metakrilata i vinil-pirolidona u različitim molarnim udjelima radikalskom polimerizacijom u otapalu butanolu. Dobiveni kopolimeri karakterizirani su sljedećim metodama: GPC (kromatografija na propusnom gelu) analiza, DSC (diferencijalna pretražna kalorimetrija) analiza, FTIR (infracrvena spektroskopija s Fourierovom transformacijom) analiza te TGA (termogravimetrijska analiza). Nakon sinteze i karakterizacije, pripremljene su polimerne otopine kopolimera u svrhu oblaganja djelatne tvari koje bi kasnije služile za razvoj farmaceutskih oblika s kontroliranim oslobađanjem lijeka. Analizom rezultata ustanovljeno je da smanjenje udjela metil-metakrilata, a povećanje vinil-pirolidona u kopolimeru doprinosi homogenosti i stabilnosti otopina. Upravo takvi stabilni sustavi su pogodni za oblaganje farmaceutika za kontrolirano otpuštanje kroz dulje razdoblje, dostavu lijeka na određeno mjesto te mogućnost prepoznavanja i reagiranja na fiziološke promjene u ljudskom organizmu.

Abstract (english)

This work presents the synthesis and characterisation of copolymers which are used for formatting pharmaceutical products. Seven copolymers were synthesized with various molar contents of methyl methachrylate and vinyl pyrrolidon by reaction of radical polymerization in butanol. Obtained copolymers were characterized by following methods: GPC analysis (gel permeation chromatography), DSC analysis (differential scanning calorimetry), FTIR analysis (Fourier-transform infrared spectroscopy) and TGA (thermogravimetric analysis). After synthesis and characterisation, polymer solutions of copolymers were prepared in order to sheathe active substances which can be used for development of pharmaceutical forms by controlled drug release. Results indicate that decrease of copolymer methyl methachrylate and increase of vinyl pyrrolidon contents in copolymer contribute to homogeneity and stability of solution. Those stable systems are suitable for sheathing pharmaceuticals over a long period, drug delivery to a specific location. Furthermore, they are suitable for identification and respond to physiological changes in human body.

• Keywords: radikalska polimerizacija; metil-metakrilat; vinil-pirolidon; GPC; DSC; FTIR; TGA; djelatna tvar
• Keywords (english): radical polymerization; methyl methacrylate; vinyl pyrrolidon; GPC; DSC; FTIR; TGA; active substance
• Language: croatian
• URN:NBN: urn:nbn:hr:149:495560
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2023-02-13 12:14:25