Razvoj metode za određivanje onečišćenja u etravirinu

master's thesis

• Title (english): Development of method for determination of impurities in etravirine
• Author: Dalibor Marijan
• Mentor: Šime Ukić (mentor)
• Committee member: Šime Ukić (predsjednik povjerenstva)
• Committee member: Dajana Kučić Grgić (član povjerenstva)
• Committee member: Matija Cvetnić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2021-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Razvoj farmacije rezultirao je poboljšanjem životnih uvjeta i produljenju ljudskog vijeka. Svaki farmaceutski pripravak prolazi kroz rigoroznu kontrolu u svakom proizvodnom koraku, kako bi se definirale nečistoće i u potpunosti izbacila mogućnost neželjenih posljedica na ljudsko zdravlje. Nečistoće se mogu identificirati nizom metoda; jedna od kojih je tekućinska kromatografija visoke djelotvornosti. U ovom radu ispitivan je HIV lijek etravirin i njegova onečišćenja. Cilj rada bio je razviti analitičku metodu za određivanje onečišćenja u etravirinu. Za razvijanje metode korišten je računalni program DryLab, a metoda je validirana je prema ICH smjernicama. Postojanje razvijene metode značajno štedi vrijeme jer su optimalni parametri analize već poznati te korisnik može računati na dobro razlučivanje analita u što kraćem vremenu analize.

Abstract (english)

Development of pharmaceutical science has resulted in the increase quality of life as well as in prolonging of the life span. Every pharmaceutical product is subject to rigorous control in every step of its synthesis, so that the present impurities could be strictly defined and the occurrence of unwanted effects for human health eliminated. Impurities can be identified using various analytical methods; one of them is high-performance liquid chromatography. This research is focused on HIV drug etravirine and its impurities. The aim was to develop an analytical method for determination of impurities in etravirine. Method development was supported by DryLab software, and the method was validated in accordance with ICH guidelines. The existence of developed method saves time significantly since all optimal analysis parameters are already known, thus an analyst can be certain of getting good peak resolution in short analysis time.

• Keywords: razvoj metode; etravirin; HPLC; validacija
• Keywords (english): method development; etravirine; HPLC; validation
• Language: croatian
• URN:NBN: urn:nbn:hr:149:987431
• Study programme: Title: Chemical Engineering - Graduate study; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2023-04-07 09:33:49