Utjecaj udjela fibroina svile na svojstva PLA/fibroin svile kompozita

master's thesis

• Title (english): The effect of silk fibroin concentration on the properties of PLA/silk fibroin composites
• Author: Mia Prpić
• Mentor: Emi Govorčin Bajsić (mentor)
• Committee member: Emi Govorčin Bajsić (predsjednik povjerenstva)
• Committee member: Nevenka Vrbos (član povjerenstva)
• Committee member: Veljko Filipan (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2021-09-24, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Polilaktidna kiselina (PLA) i fibroin svile (FS) zbog svoje biorazgradljivosti, biokompatibilnosti i netoksičnosti imaju velik potencijal za primjenu u tkivnom inženjerstvu. Cilj ovog rada bio je pripraviti PLA/FS kompozite s različitim udjelima FS te na temelju rezultata vidjeti kako fibroin svile djeluje na svojstva PLA. Provedene tehnike za karakterizaciju PLA/FS kompozita su Fourier-transformacijska infracrvena spektroskopija (FTIR-ATR), diferencijalna pretražna kalorimetrija (DSC) i termogravimetrijska analiza (TGA). Povećanjem udjela FS u kompozitima smanjen je intenzitet vrpci vezanih za PLA, ali se pojavljuju nove vrpce vezane za FS. Dodatkom FS u PLA dolazi do pomaka staklišta (Tg) i tališta (Tm) prema nižim temperaturama, što ukazuje na veću pokretljivost polimernih lanaca te narušavanje kristalne strukture. Fibroin svile djeluje kao centar nukleacije budući da se njegovim dodatkom stupanj kristalnosti povećao. Početak toplinske razgradnje pomaknut je na niže temperature u odnosu na čisti PLA, što ukazuje na smanjenje toplinske stabilnosti PLA dodatkom FS.

Abstract (english)

Polylactic acid (PLA) and silk fibroin (FS) are promising materials in tissue engineering due to their biodegradability, biocompatibility, and non-toxicity. The aim of this work was to prepare and characterize PLA/FS composites with different concentrations of FS and see how silk fibroin affects the properties of PLA. The techniques used to characterize PLA/FS composites are Fourier transform infrared spectroscopy (FTIR-ATR), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). As the concentration of FS in composites increases, the intensity of PLA absorption bands decreases and new FS absorption bands appear. The glass transition temperature (Tg) and melting temperature (Tm) of PLA decreased with the addition of FS due to higher mobility of the polymer chains and disruption of the crystal structure. Silk fibroin act as a nucleation agent since its addition increased the degree of crystallinity. With the addition of FS, the thermal stability of PLA decreased.

• Keywords: polilaktidna kiselina; fibroin svile; kompoziti; tkivno inženjerstvo
• Keywords (english): polylactic acid; silk fibroin; composites; tissue engineering
• Language: croatian
• URN:NBN: urn:nbn:hr:149:400910
• Study programme: Title: Materials Science and Engineering - Graduate study; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Closed access
• Created on: 2023-04-17 11:19:08