Razvoj metode analize aktivne supstance u farmaceutskom pripravku

undergraduate thesis

• Title (english): Development of analytical method for determination of active substance in pharmaceutical material
• Author: Dalibor Marijan
• Mentor: Tomislav Bolanča (mentor)
• Committee member: Tomislav Bolanča (predsjednik povjerenstva)
• Committee member: Šime Ukić (član povjerenstva)
• Committee member: Dajana Kučić Grgić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2019-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Razvoj farmacije rezultirao je u poboljšanju životnih uvjeta i produljenju ljudskog vijeka, no to nije bila slučajnost. Svaki farmaceutski pripravak prolazi kroz rigoroznu kontrolu na svakom sintetskom koraku, kako bi se definirale nečistoće i u potpunosti izbacila mogućnost štetnih i neželjenih posljedica na ljudsko zdravlje. Nečistoće se mogu identificirati nizom metoda, jedna od kojih je tekućinska kromatografija visoke djelotvornosti. Pri izradi ovog rada korišten je L-valinol, te njegove nečistoće etanolamin, 2-amino-1-butanol, izoleucinol, L-leucinol i alaninol. Cilj ovog rada bio je odrediti i kvantificirati nečistoće u uzorku Valinola korištenjem specifične metode te validacija iste. Korišten je HPLC uređaj pri točno definiranim uvjetima te su dobiveni udjeli nečistoća u analiziranom farmaceutskom pripravku.

Abstract (english)

Development of Pharmacy has resulted in the increase of living standards as well as prolonging the human life span. However, this is not a coincidence. Every pharmaceutical product is subject to rigorous control in every step of its synthesis, so that the present impurities could be strictly defined and the possibility of unwanted or hazardous consequences for human health eliminated. Impurities can be identified using an assortment of different methods, one of which is high-performance liquid chromatography. In making of this thesis, L-valinol and its impurities including ethanolamine, 2-amino-1-buthanol, isoleucinol, L-leucinol and alaninol were used. The aim of this thesis was to determine and quantify impurities present in a sample of valinol using a specific method and its validation. The HPLC machine was used in previously defined conditions and as a result amounts of impurities in analysed pharmaceutical substance were learned.

• Keywords: sinteza aminokiselina; onečišćenja; HPLC; validacija
• Keywords (english): amino acid synthesis; impurities; HPLC; validation
• Language: croatian
• URN:NBN: urn:nbn:hr:149:876879
• Project: Number: IP-2014-09-7992; Title: Modeliranje okolišnih aspekata napredne obrade voda za razgradnju prioritetnih onečišćivala; Title: Modeling of environmental aspects of advanced water treatment for fegradation of priority pollutants; Acronym: MEAoWT; Leader: Tomislav Bolanča; Jurisdiction: Croatia; Funder: HRZZ; Funding stream: IP
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2023-05-25 10:00:53