Predviđanje ravnotežne topljivosti djelatne tvari u čvrstom polimeru

undergraduate thesis

• Title (english): Equilibrium solubility prediction of a drug in a solid polymer
• Author: Andrea Matejaš
• Mentor: Krunoslav Žižek (mentor)
• Committee member: Krunoslav Žižek (predsjednik povjerenstva)
• Committee member: Gordana Matijašić (član povjerenstva)
• Committee member: Marko Rogošić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2019-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Lurasidon-hidroklorid je djelatna tvar izrazito male topljivosti u vodenom mediju što otežava njegovu primjenu u liječenju psihičkih poremećaja. S ciljem povećanja njegove topljivosti, metodom isparavanja otapala pripravljene su čvrste disperzije djelatne tvari u matrici hidrofilnog polimera, poli(etilen-glikola). Dobivene čvrste disperzije karakterizirane su diferencijalnom pretražnom kalorimetrijom. Prezentirana je metodologija predviđanja ravnotežne topljivosti djelatne tvari u čvrstom polimeru. Metoda počiva na termodinamičkom modelu izračuna promjene Gibbsove energije nastajanja binarne čvrste disperzije djelatna tvar-polimer. Procjenjuje se ravnotežna topljivost lurasidon-hidroklorida u poli(etilen-glikolu)
4 kDa. Dodatno, nameće se zaključak o sastavima koji će rezultirati termodinamički stabilnim čvrstim disperzijama koje će posljedično doprinijeti povećanju topljivosti djelatne tvari.

Abstract (english)

Lurasidone hydrochloride is an active pharmaceutical ingredient with extremely low aqueous solubility that makes this drug difficult to use for the treatment of psychotic disorders. For the purpose of drug solubility enhancement, solid dispersions of a drug in a matrix of hydrophilic polymer, poly(ethylene glycol), were prepared by solvent evaporation method. Derived solid dispersions were characterized by differential scanning calorimetry. A methodology is presented for predicting the equilibrium solubility of a drug in a solid polymer. The method relies on a thermodynamic model to calculate the Gibbs energy change for forming a binary drug-polymer solid dispersion. The equilibrium solubility of lurasidone hydrochloride in poly(ethylene glycol) 4 kDa is estimated. Additionally, conclusion arises on contents that will result in thermodynamically stable solid dispersions that will consequently contribute to drug solubility enhancement.

• Keywords: lurasidon-hidroklorid; poboljšanje topljivosti lijeka; čvrsta disperzija; poli(etilen-glikol); metoda isparavanja otapala; DSC analiza; termodinamički model; ravnotežna topljivost
• Keywords (english): lurasidone hydrochloride; drug solubility enhancement; solid dispersion; poly(ethylene glycol); solvent evaporation method; DSC analysis; thermodynamic model; equilibrium solubility
• Language: croatian
• URN:NBN: urn:nbn:hr:149:692403
• Study programme: Title: Environmental Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-26 08:11:33