Određivanje sadržaja lurasidon-hidroklorida u čvrstim disperzijama

undergraduate thesis

• Title (english): Determination of lurasidone hydrochloride content in solid dispersions
• Author: Katarina Sokač
• Mentor: Krunoslav Žižek (mentor)
• Committee member: Krunoslav Žižek (predsjednik povjerenstva)
• Committee member: Mirela Leskovac (član povjerenstva)
• Committee member: Irena Škorić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2019-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Lurasidon-hidroklorid je djelatna tvar izrazito male topljivosti u vodenom mediju što otežava njegovu primjenu u liječenju psihičkih poremećaja. S ciljem povećanja njegove topljivosti, metodom isparavanja otapala pripravljene su čvrste disperzije djelatne tvari u matrici hidrofilnog polimera, poli(vinil-pirolidona). Dobivene čvrste disperzije karakterizirane su diferencijalnom pretražnom kalorimetrijom i Fourier-transformiranom infracrvenom spektroskopijom. Sadržaj djelatne tvari u čvrstim disperzijama pripravljenim metodom isparavanja otapala određen je UV/Vis spektrofotometrijom i uspoređen sa sadržajem djelatne tvari u disperzijama pripravljenim metodom sušenja raspršivanjem. Bolja ujednačenost sadržaja djelatne tvari uočena je u čvrstim disperzijama pripravljenim metodom sušenja raspršivanjem.

Abstract (english)

Lurasidone hydrochloride is an active pharmaceutical ingredient with extremely low aqueous solubility that makes this drug difficult to use for the treatment of psychotic disorders. For the purpose of drug solubility enhancement, solid dispersions of a drug in a matrix of hydrophilic polymer, poly(vinylpyrrolidone), were prepared by solvent evaporation method. Derived solid dispersions were characterized by differential scanning calorimetry and Fourier- transform infrared spectroscopy. The drug content in solid dispersions prepared by solvent evaporation method was detected by UV/Vis spectrophotometry and compared with the drug content in dispersions prepared by spray drying method. Better drug content uniformity was discovered in solid dispersions prepared by spray drying method.

• Keywords: lurasidon-hidroklorid; poboljšanje topljivosti lijeka; čvrsta disperzija; poli(vinil-pirolidon); metoda isparavanja otapala; sadržaj djelatne tvari
• Keywords (english): lurasidone hydrochloride; drug solubility enhancement; solid dispersion; poly(vinylpyrrolidone); solvent evaporation method; drug content
• Language: croatian
• URN:NBN: urn:nbn:hr:149:292549
• Study programme: Title: Materials Science and Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-29 08:24:23