Uklanjanje farmaceutika iz okoliša

undergraduate thesis

• Title (english): Removal of pharmaceuticals from the environment
• Author: Helena Sudarić
• Mentor: Lidija Furač (mentor)
• Committee member: Lidija Furač (predsjednik povjerenstva)
• Committee member: Matija Cvetnić (član povjerenstva)
• Committee member: Dajana Kučić Grgić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2019-09-13, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Farmaceutici su nova onečišćivala koji predstavljaju veliku opasnost za okoliš zbog svoje visoke kemijske stabilnosti, otrovnosti te otpornosti na biološku razgradnju kao i razgradnju pod utjecajem Sunčevog zračenja. Konvencionalne metode obrade voda nisu dizajnirane za uklanjanje farmaceutika, stoga se danas razvijaju nove metode obrade za njihovo učinkovito uklanjanje. U ovom radu istraženo je uklanjanja farmaceutika escitaloprama i diazepama korištenjem UV/H2O2 i UV/Na2S2O8 naprednih oksidacijskih procesa (AOP) u ovisnosti o omjeru koncentracije modelnog onečišćivala i oksidansa. Promatran je utjecaj koncentracije oksidansa H2O2 i Na2S2O8 na brzinu raspadanja escitaloprama i diazepama pri različitim omjerima farmaceutik : oksidans (1:100, 1:300 i 1:500) HPLC metodom. Dobiveni rezultati pokazuju da razgradnja modelne otopine escitaloprama i diazepama prati kinetiku prvog reda. Također, s porastom koncentracije oksidansa, za oba sustava UV/H2O2 i UV/Na2S2O8, dolazi do smanjenja brzine raspada odabranih farmaceutika jer nastaje veći broj radikala koji počinju međusobno reagirati te stvarati nereaktivne vrste. Učinkovitiji proces uklanjanja za escitalopram i diazepam je UV/Na2S2O8 kod omjera za escitalopram:oksidans = 1:100, a diazepam:oksidans = 1:300.

Abstract (english)

Pharmaceuticals are a new type of pollutants that pose a major environmental risk because of their high chemical stability, toxicity and resistance to biodegradation as well as degradation by the influence of solar radiation. Conventional water treatment methods are not designed for removal of pharmaceuticals, so new methods are being developed for their more effective removal. This paper is based on the removal of pharmaceuticals escitalopram i diazepam using UV/H2O2 and UV/Na2S2O8 advanced oxidation processes (AOP), depending on the concentration ratio of model pollutants and oxidants. The influence of the concentration of the oxidants H2O2 and Na2S2O8 on the rate of decomposition of escitalopram and diazepam at different ratios of pharmaceutical: oxidannts (1:100, 1:300 and 1:500) was observed by HPLC. The given results show that the decomposition of the escitalopram and diazepam is following the first order kinetics. Also, with increasing concentration of oxidants, for both UV/H2O2 and UV/Na2S2O8 systems, the rate of decomposition of selected pharmaceutics decreases, as more radicals are formed that begin to react with each other and form non-reactive species. The more effective removal process for escitalopram and diazepam is UV/ Na2S2O8 at the escitalopram: oxidant = 1:100 ratio and, diazepam: oxidant = 1:300.

• Keywords: farmaceutici; napredni oksidacijski procesi; UV/H2O2; UV/Na2S2O8; kinetika; kinetika prvog reda; konstanta brzine reakcije
• Keywords (english): pharmaceuticals; advanced oxidation processes; UV/H2O2; UV/Na2S2O8; kinetics; first order kinetics; reaction rate constant
• Language: croatian
• URN:NBN: urn:nbn:hr:149:815945
• Project: Number: IP-2014-09-7992; Title: Modeliranje okolišnih aspekata napredne obrade voda za razgradnju prioritetnih onečišćivala; Title: Modeling of environmental aspects of advanced water treatment for fegradation of priority pollutants; Acronym: MEAoWT; Leader: Tomislav Bolanča; Jurisdiction: Croatia; Funder: HRZZ; Funding stream: IP
• Study programme: Title: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Advanced materials and technologies; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2023-05-29 08:56:08