Priprava i karakterizacija sekundarnih amina primjenjivih u organskoj sintezi

undergraduate thesis

• Title (english): Preparation and characterization of secondary amines for application in organic synthesis
• Author: Ivana Vujević
• Mentor: Dragana Vuk (mentor)
• Committee member: Dragana Vuk (predsjednik povjerenstva)
• Committee member: Irena Škorić (član povjerenstva)
• Committee member: Danijela Ašperger (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2023-09-07, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Sinteza sekundarnih amina provedena je reakcijom reduktivnog aminiranja aldehida primarnim aminima uz prisutnost cinka u vodenom alkalnom mediju, čime je zadovoljen i pristup zelenoj kemiji. Ovisno o vrsti početnog aldehida uspješno su sintetizirani N-heksilbenzilamin, N-etilbenzilamin i N-benzil-1-(5-metiltiofen-2-il)metanamin na sobnoj temperaturi i temperaturi refluksa otapala, pri čemu se reakcija na povišenoj temperaturi pokazala uspješnijom. Sintetizirani spojevi potvrđeni su 1H NMR spetroskopijom.

Abstract (english)

The synthesis of secondary amines was carried out by the reaction of reductive amination of aldehydes with primary amines in the presence of zinc in an aqueous alkaline medium, thus satisfying the green chemistry approach. Depending on the type of initial aldehyde, N-hexylbenzylamine, N-ethylbenzylamine and
N-benzyl-1-(5-methyltiophene-2-yl)methanamine were successfully synthesized at room temperature and solvent reflux temperature, whereby the reaction at elevated temperature proved to be more successful. The synthesized compounds were confirmed by 1H NMR spectroscopy.

• Keywords: sekundarni amini; reduktivno aminiranje; cink; zelena kemija
• Keywords (english): secondary amines; reductive amination; zinc; green chemistry
• Language: croatian
• URN:NBN: urn:nbn:hr:149:739746
• Study programme: Title: Materials Science and Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-09-12 12:04:07