Utjecaj temperature na elektrokemijsku reakciju ciklizacije N-benzilamida i N-benziltioamida

undergraduate thesis

• Title (english): The influence of temperature on the electrochemical cyclization reaction of N-benzylamides and N-benzylthioamides
• Author: Karlo Grubišić
• Mentor: Irena Škorić (mentor)
• Mentor: Goran Kragol (komentor)
• Committee member: Irena Škorić (predsjednik povjerenstva)
• Committee member: Kristina Tolić Čop (član povjerenstva)
• Committee member: Goran Kragol (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2023-09-22, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Različiti derivati 4H-1,3-benzotiazina i 4H-1,3-benzoksazina zadnjih se godina intenzivno proučavaju zbog svog potencijalnog farmakološkog djelovanja. Način njihove sinteze, ali i sinteze drugih organskih molekula, sve se više okreće ka elektrokemijskoj metodi koja prednjači kada je u pitanju ekonomičnost i ekološka prihvatljivost. U ovom je radu korištena metoda elektrokemijske dehidrogenativne ciklizacije za sintezu halogeniranih derivata navedenih spojeva, pri čemu su uspješno izolirani spojevi 6a, 6a', 6b i 7a'. Praćen je utjecaj temperature, ali i drugih čimbenika, na uspješnost reakcije. Struktura svih dobivenih spojeva potvrđena je 1H-NMR spektroskopskom metodom, a mase spojeva detektirane su na
UPLC-MS/UV uređaju.

Abstract (english)

In recent years, different derivatives of 4H-1,3-benzothiazine and 4H-1,3-benzoxazine have been extensively studied due to their potential pharmacological activity. The method of their synthesis, as well as the synthesis of other organic molecules, is increasingly shifting towards electrochemical methods, which excel in terms of cost-effectiveness and environmental friendliness. In this study, an electrochemical dehydrogenative cyclization method was employed for the synthesis of halogenated derivatives of the previously mentioned compounds, resulting in the successful isolation of compounds 6a, 6a', 6b, and 7a'.
The influence of temperature, among other factors, on the success of the reaction was monitored. The structure of all obtained compounds was confirmed using the 1H-NMR spectroscopic method, and the masses of the compounds were detected using a
UPLC-MS/UV device.

• Keywords: 4H-1 3-benzotiazin; 4H-1 3-benzoksazin; elektrokemijska sinteza; utjecaj temperature
• Keywords (english): 4H-1 3-benzothiazine; 4H-1 3-benzoxazine; electrochemical synthesis; temperature influence
• Language: croatian
• URN:NBN: urn:nbn:hr:149:978432
• Study programme: Title: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Applied organic chemistry; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-11-30 17:46:58