Tehnike pripreme i biomedicinska primjena kalcij-fosfatnih biokeramičkih prevlaka

undergraduate thesis

• Title (english): Coating technologies and biomedical application of calcium phosphate bioceramics
• Author: Ana Sikavica
• Mentor: Jozefina Katić (mentor)
• Committee member: Jozefina Katić (predsjednik povjerenstva)
• Committee member: Dajana Kučić Grgić (član povjerenstva)
• Committee member: Matija Cvetnić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2023-09-22, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Kalcij-fosfati (CaP) su najčešće korištena skupina biokeramičkih spojeva zbog dobre biokompatibilnosti, oseointegracije i osteokonduktivnosti. Njihova primjena je široka, ali najpoznatiji su po primjeni u dentalnoj i ortopedskoj medicini gdje se zbog kemijske sličnosti s kostima sisavaca koriste kao prevlake na implantatima. Implantati predstavljaju zamjenu/nadomjestak oštećenog dijela kosti ili tkiva i dizajnirani su s ciljem vraćanja funkcije oštećenom dijelu tijela. Najčešće korišteni implantni materijali su metali i njihove legure poput titanija, nehrđajućih čelika i kobalt-krom legura. U tkivnom inženjerstvu za regeneraciju i oseointegraciju kostiju površina implantata modificira se kalcij-fosfatnim prevlakama
(CaP prevlake) koje poboljšavaju i ubrzavaju procese rasta i srastanja kostiju. CaP prevlake povećavaju bioaktivnost, biokompatibilnost, otpornost na koroziju i ostala biomehanička svojstva implantnih sustava. Postoje brojne metode pripreme CaP prevlaka od kojih su one najzastupljenije opisane u ovom radu. Jedna od najšire korištenih metoda je elektrokemijsko taloženje, niskotemperaturna metoda visoke dostupnosti i niske cijene opreme. Obzirom na visoki udio starog stanovništva, i sve češće bolesti kostiju i degenerativna i upalna stanja, uključujući nekrozu i osteoporozu, uporaba tkivnog inženjerstva, odnosno potreba za regeneracijom kostiju i tkiva, sve je veća tako da su razvoj i poboljšanje implantnih sustava sa CaP prevlakama predmet konstantnih istraživanja.

Abstract (english)

Calcium phosphates (CaP) are the most commonly used group of bioceramic compounds due to their good biocompatibility, osseointegration and osteoconductivity. Their application is wide, but they are best known for use in dental and orthopedic medicine where, due to their chemical similarity to mammalian bones, they are used as coatings on implants. Implants represent a replacement/substitution of a damaged part of bone or tissue and are designed with the aim of restoring function to the damaged part of the body. The most commonly used implant materials are metals and their alloys such as titanium, stainless steel and cobaltchromium alloys. In tissue engineering for bone regeneration and osseointegration, the implant surface is modified by calcium-phosphate coatings
(CaP coatings), which improve and accelerate the processes of bone growth and fixation.
CaP coatings increase bioactivity, biocompatibility, corrosion resistance and other biomechanical properties of implant systems. There are numerous methods of preparing CaP coatings, the most common of which are described in this work. One of the most widely used method is electrochemical deposition, a low-temperature method with high availability and low cost of equipment. Due to high proportion of the elderly population, and increasingly frequent bone diseases and degenerative and inflammatory conditions (including necrosis and osteoporosis), the use of tissue engineering, i.e., the need for bone and tissue regeneration, is increasing so that the development and improvement of implant systems with CaP coatings are the subject of constant research.

• Keywords: CaP prevlake; biomaterijali; implantati; biokompatibilnost; oseointegracija
• Keywords (english): CaP coatings; biomaterials; implants; biocompatibility; osseointegration
• Language: croatian
• URN:NBN: urn:nbn:hr:149:768597
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2028-10-01
• Created on: 2023-12-01 10:59:33