Spektrofotometrijsko određivanje konstante ionizacije analoga rezveratrola

undergraduate thesis

• Title (english): Spectrophotometric determination of ionisation constant of resveratrol analogues
• Author: Jelena Škrtić
• Mentor: Sandra Babić (mentor)
• Committee member: Sandra Babić (predsjednik povjerenstva)
• Committee member: Irena Škorić (član povjerenstva)
• Committee member: Lidija Furač (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2024-09-03, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Poznavanje konstante ionizacije (Ka) izuzetno je važno prilikom razvoja novih lijekova s obzirom da nam omogućuje predviđanje ponašanja lijekova u fiziološkim uvjetima. Također, ima važnu ulogu kod određivanja ADMET (apsorpcija, distribucija, metabolizam, izlučivanje, toksičnost) svojstava lijekova. Vrijednosti pKa moguće je odrediti različitim metodama poput potenciometrije, kapilarne elektroforeze, tekućinske kromatografije te UV/VIS spektrofotometrije. U ovom radu određene su pKa vrijednosti novih analoga rezveratrola
UV/VIS spektrofotometrijskom metodom. Eksperimentalno određene pKa vrijednosti iznose: 9.80±0.09, 9.94±0.14, 9.10±0.05, 9.44±0.04 i 9.58±0.16.

Abstract (english)

The knowledge of ionisation constant (Ka) is extremly important for the development of new drugs as it allows us to predict the behavior of drugs under psysiological conditions. It also plays a crucial role in determinig the ADMET (absorption, distribution, metabolism, excretion, toxicity) prosperties of drugs. The pKa values can be determined using various methods such as potentiometry, capillary electrophoresis, liquid chromatography, and UV/VIS spectrophotometry. In this study, the pKa values of new resveratrol analogs were determined using the UV/VIS spectrophotometric method. The experimentally determined pKavalues are: 9.80±0.09, 9.94±0.14, 9.10±0.05, 9.44±0.04 and 9.58±0.16.

• Keywords: konstanta ionizacije; spektrofotometrija; rezveratrol
• Keywords (english): ionisation constant; spectrophotometry; resveratrol
• Language: croatian
• URN:NBN: urn:nbn:hr:149:862832
• Study programme: Title: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Advanced materials and technologies; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2026-09-01
• Created on: 2024-10-14 09:54:57