Utjecaj pH vrijednosti na mehanizam uklanjanja farmaceutika RO/NF membranama

master's thesis

• Title (english): Effect of pH on removal mechanism of pharmaceuticals with RO/NF membranes
• Author: Anita Puškarić
• Mentor: Krešimir Košutić (mentor)
• Committee member: Krešimir Košutić (predsjednik povjerenstva)
• Committee member: Davor Dolar (član povjerenstva)
• Committee member: Danijela Ašperger (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2016-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering; Mechanical, Thermal and Separation Processes

Abstract

U ovom radu ispitivan je utjecaj pH otopine (pH = 4, 7 i 10) na mehanizam membranskog uklanjanja odabranih farmaceutika: prazikvantela, enrofloksacina i sulfadiazina. Istraživanje je provedeno s komercijalnim reverzno osmotskim i nanofiltracijskim (RO/NF) membranama: XLE, UTC-70HA, BW30, NF, NF90 i NF270. Zadržavanje farmaceutika analizirano je na osnovu njihove veličine molekula, naboja i hidrofilnosti u odnosu na karakteristike membrana. S povećanjem pH vrijednost otopine, povećava se negativni naboj površine membrane, a pri pH vrijednostima ispod pKa komponente se adsorbiraju i raspodjeljuju kroz membranu. Pri pH iznad pKa, adsorpcija komponenata je minimalna zbog povećane topljivosti pa utjecaj elektrostatskog odbijanja postaje značajan. Zaključno, na učinkovitost uklanjanja farmaceutika prvenstveno utječe mehanizam isključenja po veličini, ali je potrebno uzeti u obzir i utjecaj međudjelovanja farmaceutika i membrana.

Abstract (english)

In this work the effect of pH (pH = 4, 7, 10) on the rejection mechanism of selected pharmaceuticals (praziquantel, enrofloxacin, sulfadiazine) was studied. Several commercial RO/NF (XLE, UTC-70HA, BW30, NF, NF90, NF270) membranes were studied at different pH values. Their retention and flux were explained by the size exclusion, charge and the hydrophilic/hydrophobic characteristics of selected components and membranes. Increasing pH, resulted in an increased negative surface charge, at the pH below the pKa selected components adsorbed and partitioned through the membrane. At the pH above the pKa, adsorption of components was minimal due to an increased solubility and the significant role of electrostatic repulsion. The effectiveness of removing pharmaceuticals from model water with RO/NF membranes was influenced by size exclusion mechanism and the interaction between pharmaceuticals and membranes. Dominant rejection mechanism of the examined pharmaceuticals was the size exclusion.

• Keywords: reverzna osmoza; nanofiltracija; pH otopine; farmaceutici; uklanjanje
• Keywords (english): reverse osmosis; nanofiltration; pH effect; pharmaceutical; retention
• Language: croatian
• URN:NBN: urn:nbn:hr:149:656218
• Study programme: Title: Applied Chemistry - Graduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Environmental chemistry and green technologies; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra primijenjene kemije (magistar/magistra primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-07-06 08:36:18