Metode priprave poroznih skeleta za biomedicinske primjene

undergraduate thesis

• Title (english): Preparation methods of porous scaffolds for biomedical applications
• Author: Marija Posarić
• Mentor: Marica Ivanković (mentor)
• Committee member: Marica Ivanković (predsjednik povjerenstva)
• Committee member: Jelena Macan (član povjerenstva)
• Committee member: Dajana Milovac (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2015-09-03, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Basic Technical Sciences; Materials

Abstract

Cilj ovog rada je dati kratki literaturni pregled metoda priprave poroznih skeleta koji se koriste u području inženjerstva tkiva. Inženjerstvo tkiva je interdiscplinarno područje u nastajanju koje primjenjuje načela prirodnih znanosti i inženjerstva za proizvodnju inženjerskog tkiva za popravak i zamjenu oštećenih tkiva i organa.
U inženjerstvu tkiva glavnu ulogu imaju skeleti. Skeleti su trodimenzijske strukture napravljene od bioloških materijala i biomaterijala, koji ispunjavaju osnovne zahtjeve za vezanje i rast stanica. Skeleti napravljeni od polimera, keramike ili kompozita moraju posjedovati specifične karakteristike kao što su visoka poroznost, velika specifična površina, strukturna čvrstoća, specifični trodimenzijski oblik, biokompatibilnost i biorazgradivost.
U radu su izdvojene četiri uspješne metode izrade visoko poroznih polimernih i kompozitnih skeleta: elektropredenje, liofilizacija, ispiranje čestica porogena i toplinski potaknuto razdvajanje faza. Svaka od metoda ima jedinstvene prednosti u proizvodnji skeleta za inženjerstvo tkiva.

Abstract (english)

The aim of this work is to give a brief literature review of methods for preparing porous scaffolds used in tissue engineering. Tissue engineering is an interdisciplinary field that applies the principles of life science and engineering to produce engineered tissues for the repair and replacement of damaged tissues or organs.
In tissue engineering, scaffolds play a crucial role. Scaffolds are three-dimensional structures made from biological materials and biomaterials, which fulfil the necessary requirements for cell attachment and growth. Scaffolds made of polymers, ceramics or composites; have to possess specific characteristics such as high porosity, high surface area, three-dimensional shape, biocompatibility and biodegradability.
In this work, four successful methods for highly porous polymer and composite scaffold preparation are pointed out: electrospinning, freeze-drying, particulate leaching and thermally induced phase separation. Each method has unique advantages in the production of scaffolds for tissue engineering.

• Keywords: skelet; inženjerstvo tkiva; poroznost
• Keywords (english): scaffolds; tissue engineering; porosity
• Language: croatian
• URN:NBN: urn:nbn:hr:149:280454
• Study programme: Title: Materials Science and Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-09-20 13:46:37