Razumijevanje međuodnosa UV filtri - farmaceutski aktivne tvari tijekom fotolitičkih procesa

master's thesis

• Title (english): Understanding intrastressor behaviour during phototransformation processes: UV filters - pharmaceutically active compounds
• Author: Ana-Marija Čižmek
• Mentor: Sandra Babić (mentor)
• Committee member: Sandra Babić (predsjednik povjerenstva)
• Committee member: Irena Škorić (član povjerenstva)
• Committee member: Marko Rožman (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2017-09-25, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry; Analytic Chemistry

Abstract

Farmaceutici i UV-filtri sastavni su dio smjese onečišćivača u slatkovodnim sustavima. Zahvaljujući fotostabilnosti i apsorpcijskim svojstvima UV–filtri mogu inhibirati utjecaj UV–zračenja te na taj način potencijalno utjecati na fotolitičku razgradnju farmaceutika. U ovom radu ispitana je fotolitička razgradnja farmaceutika iz sedam skupina antibiotika: enrofloksacin, eritromicin, trimetoprim, oksitetraciklin, sulfametoksazol, vankomicin i amoksicilin. Fotolitička razgradnja pod utjecajem umjetnog Sunčevog zračenja praćena je u tri vodene matrice (ultračista, izvorska te sintetska otpadna voda, s ili bez prisutnosti UV-filtara. Rezultati ukazuju da fotolitička razgradnja predstavlja važan proces razgradnje amoksicilina, enrofloksacina, eritromicina, oksitetraciklina, sulfametoksazola i vankomicina, dok trimetoprim nije podložan fotolitičkoj razgradnji. Opažen je statistički značajan utjecaj matrice na brzinu fotorazgradnje većine proučavanih antibiotika. Utvrđeno je da prisutnost UV-filtara smanjuje brzinu ili zaustavlja fotolitičku razgradnju proučavanih antibiotika u odnosu na otopine u koje nisu dodani filtri. Navedeno ukazuje na međuodnose unutar smjese onečišćivača koji mijenjaju sudbinu istih, te produžuju vrijeme njihovog zadržavanja u okolišu.

Abstract (english)

Pharmaceuticals and UV-filters are ubiquitous members of pollutant mixture in environmental waters. Due to photostability and absorption properties, UV-filters can inhibit the impact of UV irradiation thus potentially affecting photolytic degradation of pharmaceuticals. In this work the photolytic degradation of pharmaceuticals from seven groups of antibiotics (enrofloxacin, erythromycin, trimethoprim, oxytetracycline, sulfamethoxazole, vancomycin and amoxicillin) was investigated. The photolysis of these antibiotics as well as their interactions with UV filters under artificial solar light was studied within three aqueous matrices (ultra-pure, spring and synthetic wastewater). The results indicate photolytic degradation as an important degradation process for amoxicillin, enrofloxacin, erythromycin, oxytetracycline, sulfamethoxazole and vancomycin while trimethoprim was not susceptible to photodegradation. A statistically significant effect of the matrix on the photodegradation rate of the antibiotics was observed. Furthermore, it was found that the presence of UV filters can reduce or even stop the photolysis rate. Thus, the environmental fate of particular contaminant can be influenced by the presence of other chemicals from the mixture i.e. contaminants may persist longer in the environment.

• Keywords: farmaceutici; antibiotici; UV-filtri; fotolitička razgradnja; UV zračenje
• Keywords (english): pharmaceuticals; antibiotics; UV-filters; photolytic degradation; UV irradiation
• Language: croatian
• URN:NBN: urn:nbn:hr:149:358724
• Study programme: Title: Materials Science and Engineering - Graduate study; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-04-22 10:33:21