Analiza i simulacija procesa kristalizacije

master's thesis

• Title (english): Crystallization process analysis and simulation
• Author: Ivan Vrban
• Mentor: Nenad Bolf (mentor)
• Committee member: Nenad Bolf (predsjednik povjerenstva)
• Committee member: Jasna Prlić Kardum (član povjerenstva)
• Committee member: Ozren Wittine (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2019-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Zbog iznimne važnosti i utjecaja raspodjele veličine čestica na procese koji slijede nakon kristalizacije (filtracija i sušenje) u farmaceutskoj proizvodnji razvijaju se nove tehnologije za in situ praćenje raspodjele veličine čestica tijekom procesa kristalizacije. U radu se pratila linijska raspodjela veličina čestica primjenom sonde za mjerenje refleksije usredotočene zrake na temelju čega je izveden model neuronske mreže za korelaciju linijske raspodjele veličine čestica s volumnom raspodjelom veličina čestica. Razvijeno je šest neuronskih mreža različitih struktura. Modeli neuronske mreže razvijeni na bimodalnoj raspodjeli fosamprenavir kalcija ostvarili su visoko slaganje pri ispitivanju na nezavisnom skupu podataka.

Abstract (english)

Due to importance of particle size distribution to the downstream processing (filtering and drying), new technologies are being developed for in situ monitoring of particle size distribution during crystallization. In the presented work chord length distribution was measured with FBRM sensor while neural network model for correlating chord length distribution and particle size distribution was developed. Six neural networks with different structure were developed. Neural network models were developed on the bimodal distribution of fosamprenavir calcium and describe independent dataset with high agreement.

• Keywords: kristalizacija; volumna raspodjela veličina čestica; linijska raspodjela veličina čestica; sonda za mjerenje refleksije usredotočene zrake; neuronska mreža
• Keywords (english): crystallization; particle size distribution; chord length distribution; FBRM; neural network
• Language: croatian
• URN:NBN: urn:nbn:hr:149:059827
• Study programme: Title: Chemical Engineering - Graduate study; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-02-27 19:20:40