Sorpcija memantina na prirodne uzorke tla i sedimente

undergraduate thesis

• Title (english): Sorption of memantine on natural soil and sediment samples
• Author: Ivan Lukač
• Mentor: Dragana Mutavdžić Pavlović (mentor)
• Committee member: Dragana Mutavdžić Pavlović (predsjednik povjerenstva)
• Committee member: Sandra Babić (član povjerenstva)
• Committee member: Tatjana Gazivoda Kraljević (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2018-09-18, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry; Analytic Chemistry

Abstract

Farmaceutici se koriste za liječenje i prevenciju bolesti u ljudi i životinja. Rigoroznim testiranjima se prati utjecaj farmaceutika na njihovo zdravlje. No veliki je problem da se negativne nuspojave koji farmaceutici mogu imati na okoliš sve do relativno nedavno nisu proučavale u istoj mjeri. Najčešći izvori farmaceutika u okolišu su procesi proizvodnje farmaceutika te kanalizacijski sustavi u kojima se preostali farmaceutici iz ljudskog i životinjskog izmeta vraćaju u ciklus vode. Pojava memantina na tlu i sedimentu se također može pripisati tim procesima kruženja vode koja onda dolazi u kontakt s određenim tlom/sedimentom. Sorpcija je pojava vezanja tekuće faze s krutom fazom. Koliko će se neka tvar iz tekuće faze dobro vezati za čvrstu fazu ovisi o svojstvima otopljene tvari u tekućoj fazi kao i o fizikalno-kemijskim svojstvima čvrste faze. Memantin je farmaceutik koji se koristi u liječenju srednje i napredne Alzheimerove bolesti i preporučuje se kao opcija tijekom liječenja onih pacijenata koji su netolerantni na AChE inhibitore. Budući da je u uporabi tek od 1989. godine, njegov utjecaj na okoliš još je uvelike nepoznat. Kako bi se odredio utjecaj memantina na okoliš provodilo se istraživanje sorpcije memantina na 5 prirodnih uzoraka tla i 5 uzoraka sedimenta iz Republike Hrvatske. Proučavao se utjecaj fizikalno-kemijskih svojstava tla i sedimenta poput udjela humusa te pH i ionske jakosti na proces sorpcije. Određena je kinetika procesa sorpcije i desorpcije memantina.

Abstract (english)

Pharmaceuticals are used for the treatment and prevention of diseases in humans and animals. Rigorous testing is used to monitor the effects on their health. However it is a big problem that the negative side effects that pharmaceuticals can have on the environment have not been studied in a similar manner up until recently. The most common sources of pharmaceuticals in the environment are the process of producing the pharmaceutical and the canalisation system through which leftover pharmaceuticals in human and animal waste reenter the water cycle. The appearance of memantine in soil and sediments can also be attributed to these water cycling procesess from which the water then comes into contact with a particular soil/sediment. Sorption is the process by which a liquid phase binds itself to a solid phase. How well a given particle from the liquid phase will bond to the solid phase is dependent upon the properties of the liquid phase as well as the physico-chemical properties of the solid phase. Memantine is a pharmaceutical used in treating mild to serious Alzheimer's disease and is recommended as an option during the treatment of those patient who are intolereant to AchE inhibitors. Since, it has been only in use since 1989. its impact on the environment is still unknown. In order to determine the effects of memantine on the environment we've conducted research into the sorption of memantine onto 5 natural soil and 5 natural sediment samples from the territory of the Repubilc of Croatia. The effect of the physico-chemical properties such as the humus or the pH and ionic strength on sorption process have been studied. Kinetic of memantine sorption and desorption process were determined.

• Keywords: sorpcija; memantin; prirodno tlo i sediment
• Keywords (english): memantine; sorption; natural sediment and soil
• Language: croatian
• URN:NBN: urn:nbn:hr:149:031969
• Project: Number: IP-2014-09-2353; Title: Sudbina farmaceutika u okolišu i tijekom naprednih postupaka obrade voda; Title: Fate of pharmaceuticals in the environment and during advanced wastewater treatment; Acronym: PharmaFate; Leader: Sandra Babić; Jurisdiction: Croatia; Funder: HRZZ; Funding stream: IP
• Study programme: Title: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Environmental chemistry and green technologies; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-05-17 13:23:15