Elektroispredanje: tehnološki pristup za pripravu novog tipa čvrste disperzije za slabo topljive djelatne tvari

undergraduate thesis

• Title (english): Electrospinning: a technological approach to prepare a new type of solid dispersion for poorly soluble drugs
• Author: Sara Vranko
• Mentor: Krunoslav Žižek (mentor)
• Committee member: Krunoslav Žižek (predsjednik povjerenstva)
• Committee member: Gordana Matijašić (član povjerenstva)
• Committee member: Juraj Šipušić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2022-09-22, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Ovaj rad je sažet i stručan pregled razvoja, značaja i primjene elektroispredanja s naglaskom na područje zaštite zdravlja ljudi. Farmaceutska industrija se pri formulaciji novih lijekova susreće s problemom topljivosti djelatnih tvari u vodenom mediju. Razvijene su razne metode za rješenje tog problema, a dijele se na fizičke i kemijske. Priprava čvrstih disperzija pokazala se kao jednom od uspješnijih te pripada kategoriji fizičkih metoda. Čvrste disperzije, koje se sastoje od hidrofilne matrice i hidrofobne djelatne tvari, mogu se pripremiti na razne načine, no neki od najčešće upotrebljavanih su: metoda taljenja, metoda isparavanja otapala i ekstruzija vruće taline. Valja naglasiti kako se u novije vrijeme razvila i tehnika elektroispredanja kao potencijalna metoda za pripravu čvrstih disperzija. Istraživanjima je dokazano da elektroispredanje može značajno doprinijeti povećanju topljivosti djelatne tvari, odnosno da se tehnikom elektroispredanja mogu uspješno pripraviti binarne i ternarne čvrste disperzije slabo topljivih djelatnih tvari. Prati se značajan napredak u formulaciji farmaceutskih pripravaka poboljšanih svojstava upravo tehnikom elektroispredanja u usporedbi s konvencionalnim metodama.

Abstract (english)

This thesis is a concise and expert overview of the development, significance and application of electrospinning with emphasis on the field of human health protection. In the formulation of new drugs, the pharmaceutical industry faces the problem of drug solubility in aqueous medium. Various methods have been developed to solve this problem, which are divided into physical and chemical methods. The preparation of solid dispersions has proved to be one of the most successful and belongs to the category of physical methods. Solid dispersions, which consist of a hydrophilic matrix and a hydrophobic active ingredient, can be prepared in various ways, but some of the most commonly used methods are: melting, solvent evaporation and melt extrusion. It should be noted that electrospinning technique has recently been developed as a potential method for the preparation of solid dispersions. Studies have demonstrated that electrospinning can significantly contribute to the improvement of drug solubility, i.e., binary and ternary solid dispersions of poorly soluble drugs can be successfully prepared using electrospinning technique. Significant progress is being made in the formulation of pharmaceutical preparations with improved properties precisely by the electrospinning technique compared to conventional methods.

• Keywords: djelatna tvar; poboljšanje topljivosti lijeka; čvrsta disperzija; elektroispredanje; nanovlakna
• Keywords (english): drug; drug solubility improvement; solid dispersion; electrospinning; nanofibers
• Language: croatian
• URN:NBN: urn:nbn:hr:149:212387
• Study programme: Title: Environmental Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2022-09-22
• Created on: 2023-03-14 12:26:00