Sinteza gvanidinskih derivata kinoksalina

master's thesis

• Title (english): Synthesis of guanidine derivatives of quinoxalines
• Author: Matea Bačan Peškir
• Mentor: Irena Škorić (mentor)
• Mentor: Davor Margetić (komentor)
• Committee member: Irena Škorić (predsjednik povjerenstva)
• Committee member: Dragana Vuk (član povjerenstva)
• Committee member: Davor Margetić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2022-09-12, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Cilj ovoga rada bio je dobiti spojeve 17, 18, 19, 20 i 21 te ih spektroskopski karakterizirati. Također, na primjeru jednog niza reakcija uspoređena su iskorištenja reakcija provedenih klasičnim putem u otopini i onih provedenih mehanokemijski. Navedeni spojevi dobiveni su reakcijama kondenzacije, redukcije, gvaniliranja te deprotekcije. Kao početni spojevi koristili su se alkilirani nitroizatin odnosno izatin i odgovarajući diamin. Naknadno će u drugom laboratoriju biti ispitana njihova svojstva vezanja na DNA i RNA.

Abstract (english)

The aim of this work was to obtain compounds 17, 18, 19, 20 and 21 and characterize them spectroscopically. Also, on the example of a series of reactions, the efficiency of reactions carried out by the classical method in solution and those carried out mechanochemically were compared. Those compounds were obtained by condensation, reduction, guanylation and deprotection reactions. Alkylated nitroisatin or isatin and the corresponding diamine were used as starting compounds. At some point in the future their binding properties to DNA and RNA will be tested in another laboratory.

• Keywords: gvanidin; kinoksalin; indol; gvaniliranje; reakcije u otopini; mehanokemija
• Keywords (english): guanidine; quinoxaline; indole; guanylation; reactions in solution; mechanochemistry
• Language: croatian
• URN:NBN: urn:nbn:hr:149:095498
• Study programme: Title: Applied Chemistry - Graduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Applied organic chemistry; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra primijenjene kemije (magistar/magistra primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-03-19 16:14:52