In vitro oslobađanje djelatne tvari iz transdermalnih pripravaka

undergraduate thesis

• Title (english): In vitro release of the active ingredient from transdermal system
• Author: Magda Meštrović
• Mentor: Gordana Matijašić (mentor)
• Committee member: Gordana Matijašić (predsjednik povjerenstva)
• Committee member: Krunoslav Žižek (član povjerenstva)
• Committee member: Juraj Šipušić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2021-07-09, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Cilj ovoga rada je provesti in vitro ispitivanje oslobađanja celekoksiba iz transdermalnog pripravka. Ispitivanje se provodi upotrebom Franzovih difuzijskih ćelija, a prvi je zadatak savladavanje metode in vitro ispitivanja. Dobiveni podaci se obrađuju kako bi se proveo odabir odgovarajućeg kinetičkog modela kojim bi se potencijalno mogao opisati prijelaz djelatne tvari iz transdermalnog pripravka u sistemsku cirkulaciju. Za analizu kinetičkih modela koristi se dodatak za Microsoft Excel program, DDSolver. Prema dobivenim podacima, oslobađanje celekoksiba iz transdermalnog pripravka opisuje se Korsmeyer-Peppasovim kinetičkim modelom. Taj model definiran je dvama parametrima: konstantom brzine oslobađanja djelatne tvari (kr) i eksponentom difuzije (n) koji za ovaj model poprima vrijednosti u intervalu od 0,5 do 1. U tom slučaju, mehanizam oslobađanja djelatne tvari opisuje se difuzijom koja odstupa od Fickova zakona, tzv. anomalnom difuzijom.

Abstract (english)

The aim of this work is to study the in vitro release of celecoxib from the transdermal system. For this purpose Franz diffusion cells are used and it is important to master the in vitro release method. The results are analyzed to determine which kinetic model is appropriate for the observed drug release from the transdermal system into a systemic circulation. With the intention of analyzing kinetic models, Microsoft Excel's DDSolver program is used. According to the results, the Korsmeyer-Peppas model describes the release of celecoxib from the transdermal system. This model is defined by two parameters: release constant (kr) and diffusion exponent (n), which is in the range of 0.5 and 1. In this case, the release mechanism is described with anomalous diffusion. Thus, Fick’s diffusion law cannot describe the release mechanism of celecoxib.

• Keywords: in vitro; celekoksib; transdermalni pripravak; Franzova ćelija; Korsmeyer-Peppas
• Keywords (english): in vitro; celecoxib; transdermal system; Franz cell; Korsmeyer-Peppas
• Language: croatian
• URN:NBN: urn:nbn:hr:149:733845
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-04-11 07:21:12