Procjena ravnotežne topljivosti djelatne tvari u amorfnom polimeru primjenom toplinske analize i termodinamičkog modeliranja

undergraduate thesis

• Title (english): Estimating the equilibrium solubility of a drug in amorphous polymer using thermal analysis and thermodynamic modelling
• Author: Tena Murk
• Mentor: Krunoslav Žižek (mentor)
• Committee member: Krunoslav Žižek (predsjednik povjerenstva)
• Committee member: Marko Rogošić (član povjerenstva)
• Committee member: Jelena Macan (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2020-09-04, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Lurasidon-hidroklorid je djelatna tvar izrazito male topljivosti u vodenom mediju što otežava njegovu primjenu u liječenju psihičkih poremećaja. S ciljem povećanja njegove topljivosti, metodom isparavanja otapala pripravljene su čvrste disperzije djelatne tvari u matrici hidrofilnog polimera, poli(vinil-pirolidona). Dobivene čvrste disperzije karakterizirane su diferencijalnom pretražnom kalorimetrijom. Korištena je metodologija predviđanja ravnotežne topljivosti djelatne tvari u amorfnom polimeru. Metoda počiva na termodinamičkom modelu izračuna slobodne Gibbsove energije miješanja binarne čvrste disperzije djelatna tvar-polimer. Procijenjena je topljivost lurasidon-hidroklorida u poli(vinil-pirolidonu) 58 kDa. Dodatno, nameće se zaključak o sastavima koji će rezultirati termodinamički stabilnim čvrstim disperzijama koje će posljedično doprinijeti povećanju topljivosti djelatne tvari.

Abstract (english)

Lurasidone hydrochloride is an active pharmaceutical ingredient of extremely low aqueous solubility that makes this drug difficult to use for the treatment of psychotic disorders. For the purpose of drug solubility enhancement, solid dispersions of a drug in a matrix of hydrophilic polymer, poly(vinyl-pyrrolidone), were prepared by solvent evaporation method. Derived solid dispersions were characterized by differential scanning calorimetry. The methodology was used for estimating the equilibrium solubility of a drug in an amorphous polymer. The method relies on a thermodynamic model to calculate the Gibbs free energy for mixing a binary drug-polymer solid dispersion. The solubility of lurasidone hydrochloride in poly(vinyl-pyrrolidone) 58 kDa was estimated. Additionally, conclusion arises on contents that will result in thermodynamically stable solid dispersions that will consequently contribute to drug solubility enhancement.

• Keywords: lurasidon-hidroklorid; poboljšanje topljivosti lijeka; čvrsta disperzija; poli(vinil-pirolidon); DSC analiza; termodinamički model; topljivost djelatne tvari u polimeru
• Keywords (english): lurasidone hydrochloride; drug solubility enhancement; solid dispersion; poly(vinyl-pyrrolidone); DSC analysis; thermodynamic model; drug solubility in polymer
• Language: croatian
• URN:NBN: urn:nbn:hr:149:528130
• Study programme: Title: Environmental Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-08 08:41:05