Sušenje raspršivanjem kao metoda povećanja topljivosti djelatne tvari

undergraduate thesis

• Title (english): Spray drying as a method for improvement of drug solubility
• Author: Mario Sokolić
• Mentor: Gordana Matijašić (mentor)
• Committee member: Gordana Matijašić (predsjednik povjerenstva)
• Committee member: Jasna Prlić Kardum (član povjerenstva)
• Committee member: Nevenka Vrbos (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2019-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Topljivost lijekova predstavlja veliki problem u farmaceutskoj industriji zbog nemogućnosti, sporog ili nepotpunog oslobađanja djelatne tvari. Problem predstavlja kristalna struktura djelatne tvari zbog koje dolazi do slabijeg otapanja unutar krvotoka ili želudca. Postoje mnoge metode koje se koriste kako bi se povećala topljivost koje se uglavnom temelje na pripravi amorfnog uzorka iz kristalnog oblika lijeka. U ovom radu provedeno je sušenje otopina celekoksiba raspršivanjem. Ispitan je utjecaj otapala te promjene protoka zraka za raspršivanje na svojstva konačnih uzoraka te in vitro oslobađanje celekoksiba. Uzorci su analizirani razlikovnom pretražnom kalorimetrijom (DSC) i rendgenskom difrakcijom (XRPD). Ispitana je topljivost dobivenih uzoraka. In vitro metodom dobiveni su profili oslobađanja celekoksiba koji su uspoređeni izračunom statističkih pokazatelja, faktora sličnosti i faktora razlike. Rezultati su pokazali da je metodom sušenja raspršivanjem dobivena bolja topljivost celekoksiba i njegovo brže oslobađanje in vitro. XRPD difraktogrami ukazuju da sušenjem nije došlo do promjene iz kristalne u amorfnu fazu zbog čega se zaključuje da je povećanje topljivosti posljedica promjene u obliku i raspodjeli veličina čestica. Faktori sličnosti pokazuju statistički značajnu razliku profila oslobađanja.

Abstract (english)

The solubility of drugs is a major problem in the pharmaceutical industry due to the inability, slow or incomplete release of the active substance. The major problem is the crystalline form of the active substance that causes it to dissolve poorly within the bloodstream or stomach. There are many methods used to increase the solubility based mainly on the preparation of an amorphous sample from the crystalline form of the drug. Spray drying of celecoxib solutions was performed in this work. The effect of solvents and changes in the flow of atomization air on the properties of the final samples and the in vitro release of celecoxib were examined. Samples were analyzed by differential scanning calorimetry (DSC) and X-ray diffraction (XRPD). The solubility of the samples obtained was tested. In vitro celecoxib release profiles were obtained and compared by calculating statistical indicators, similarity factor and difference factor. The results showed that the spray drying method gave better solubility of celecoxib and its faster in vitro release. XRPD diffractograms indicate that drying did not change from crystalline to amorphous phase, which leads to the conclusion that the increase in solubility was due to a change in the particle shape and particle size distribution. Similarity factors show a statistically significant difference in the release profiles.

• Keywords: celekoksib; sušenje raspršivanjem; in vitro ispitivanje; faktor sličnosti; DSC; XRPD
• Keywords (english): celecoxib; spray drying; in vitro tests; similarity factor; DSC; XRPD
• Language: croatian
• URN:NBN: urn:nbn:hr:149:328718
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-29 08:31:59