"One-pot" sinteza novih derivata benztiazola

undergraduate thesis

• Title (english): "One-pot" synthesis of novel benzothiazole derivatives
• Author: Nika Žuža
• Mentor: Tatjana Gazivoda Kraljević (mentor)
• Committee member: Tatjana Gazivoda Kraljević (predsjednik povjerenstva)
• Committee member: Andrijana Meščić Macan (član povjerenstva)
• Committee member: Dajana Kučić Grgić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2019-07-04, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

U ovom radu opisana je „one-pot“ sinteza 6-(4-aril/alikl-1,2,3-triazolil)-2-arilbenztiazola, u jednoj reakcijskoj posudi bez izolacije međuprodukata. 6-azido derivati benztiazola nastaju in situ reakcijom 6-amino-2-arilbenztiazola s tert-butilnitritom i TMSN3. Klik reakcijom kataliziranom bakrom nastalih 6-azidobenztiazola i odgovarajućih terminalnih alkina priređeni su derivati benztiazola supstituirani u položaju 2 arilnim supstituentom i 4-supstituiranim 1,2,3-triazolnim prstenom u položaju 6. Strukture svih novopriravljenih spojeva potvrđene su 1H-NMR spektroskopijom.

Abstract (english)

This paper describes "one- pot" synthesis of
6-(4-aryl/alkyl-1,2,3-triazolyl)-2-arylbenzothiazole in one reaction vessel without isolation of the intermediates. 6-azido benzothiazole derivatives are synthesized in situ by reaction of 6-amino-2-arylbenzothiazole with tert-butylnitrite and TMSN3. Copper catalyzed click reaction of 6-azidobenzothiazole and corresponding terminal alkynes gave benzothiazole derivatives substituted at position 2 with aryl substituents and with 4-substituted 1,2,3-triazole ring at position 6. The structures of all novel compounds were confirmed by 1H-NMR spectroscopy.

• Keywords: "One-pot"; benztiazol; klik kemija
• Keywords (english): "One-pot"; benzothiazole; click chemistry
• Language: croatian
• URN:NBN: urn:nbn:hr:149:888216
• Project: Number: IP-2018-01-4682; Title: Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja; Acronym: PurBioCaPa; Leader: Silvana Raić-Malić; Jurisdiction: Croatia; Funder: HRZZ; Funding stream: IP
• Study programme: Title: Environmental Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2022-10-01
• Created on: 2023-05-29 13:36:25