Utjecaj višenamjenskih pomoćnih tvari na profil oslobađanja djelatne tvari

master's thesis

• Title (english): The effect of multi-functional excipients on the drug release profile
• Author: Leonora Rivić
• Mentor: Krunoslav Žižek (mentor)
• Committee member: Krunoslav Žižek (predsjednik povjerenstva)
• Committee member: Dragana Vuk (član povjerenstva)
• Committee member: Matija Cvetnić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Glavni cilj ovog eksperimentalnog istraživanja je ispitati utjecaj višenamjenskih pomoćnih tvari na profil oslobađanja lurasidon-hidroklorida. Formulacijom lijeka s pažljivo odabranim funkcionaliziranim pomoćnim tvarima moguće je priparaviti dozorni oblik ciljanih primjenskih svojstava. U ovom istraživanju pripremane su tablete lurasidon-hidroklorida koje se razlikuju po granulometrijskim te morfološkim svojstvima funkcionalizirane pomoćne tvari - manitola. Kompresibilna svojstva D(-) manitola znatno su poboljšana granuliranjem. Provedena je detaljna granulometrijska i morfološka analiza različitih manitola. Granulometrijske karakteristike punila dovedene su u vezu s profilom oslobađanja djelatne tvari. Najbolji profil oslobađanja lurasidon-hidroklorida pokazuju tablete s višenamjenskim pomoćnim tvarima M200 + PLX188.

Abstract (english)

The main objective of this experimental study is to investigate the effect of multi-functional excipients on the release profile of lurasidone hydrochloride. By formulating drugs with carefully selected functionalized excipients, it is possible to prepare dosage form of aimed end-use properties. In this research, lurasidone hydrochloride tablets were prepared with different granulometric and morphological properties of the functionalized excipient mannitol. Compressive properties of D(-)-mannitol are significantly improved by granulation. Detailed granulometric and morphological analyses were carried out. The granulometric properties of the filler are linked to the release profile of the drug. The best release profile of lurasidone hydrochloride was found for tablets with multi-functional excipients M200 + PLX188.

• Keywords: lurasidon-hidroklorid; poboljšanje topljivosti lijeka; višenamjenske pomoćne tvari; oslobađanje djelatne tvari
• Keywords (english): lurasidone hydrochloride; drug solubility enhancement; multi-functional excipients; drug release
• Language: croatian
• URN:NBN: urn:nbn:hr:149:964615
• Study programme: Title: Environmental Engineering - Graduate study; Study programme type: university; Study level: graduate; Academic / professional title: sveučilišni/a magistar/magistra inženjer/inženjerka ekoinženjerstva (sveučilišni/a magistar/magistra inženjer/inženjerka ekoinženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-07-15 14:40:52