Spektroskopska karakterizacija benzo[b]tieno-2-karboksamida u prisustvu metalnih kationa korištenjem UV/Vis i fluorimetrijske spektroskopije

undergraduate thesis

• Title (english): Spectroscopic characterization of benzo[b]thieno-2-carboxamides in the presence of metal cations by UV/Vis and fluorimetric spectroscopy
• Author: Adriana Katavić
• Mentor: Marijana Hranjec (mentor)
• Committee member: Marijana Hranjec (predsjednik povjerenstva)
• Committee member: Nataša Perin (član povjerenstva)
• Committee member: Jasna Prlić Kardum (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2016-09-09, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry; Organic Chemistry

Abstract

U okviru ovog rada priređeni su derivati benzo[b]tiofen-2-karboksamida kao potencijalni biološki aktivni spojevi. Za pripravu ciljanih molekula korištene su klasične metode organske kemije. Ciljani derivati 6a-6d priređeni su reakcijom kondenzacije odgovarajućih anilina 5a-5c i 3-klor-benzo[b]tiofen-2-karbonil-klorida 4a i 4b. Ciljani amino supstituirani derivati 6e i 6f priređeni su redukcijom NO2 supstituiranih derivata 6b i 6d. Struktura priređenih karboksamida potvrđena je korištenjem 1H i 13C NMR spektroskopije, a spojevi su dodatno okarakterizirani UV/Vis i fluorimetrijskom spektroskopijom. Da bi se potvrdila moguća primjena ovih spojeva kao senzora za određivanje kationa u otopinama ili za detekciju pH, provedene su i UV/Vis i fluorimetrijske titracije otopina spojeva s otopinama metalnih soli ili u puferima različitog pH.

Abstract (english)

The aim of this study was the synthesis of benzo[b]thieno-2-carboxamide derivatives as potential biologically active compounds. For the preparation of target molecules, classical methods of organic synthesis were used. Targeted compounds 6a-6d are prepared in the condensation of appropriate anilines 5a-5c and 3-chlorobenzo[b]thiophene-2-carbonyl chlorides 4a and 4b. Amino substituted compounds 6e and 6f are prepared by reduction of nitro substituted compounds 6b and 6d. The structures of all synthesized compounds were confirmed by means of 1H and 13C NMR spectroscopy and also the prepared compounds were additionally characterized by UV/Vis and fluorimetric spectroscopy. To explore the possibility of synthesized compounds for their application as chemosensors for detection of cations or pH sensors, UV/Vis and fluorimetric titrations of aqueous compounds solutions with aqueous solutions of metal chloride salts or with buffers having different pH were performed.

• Keywords: benzo[b]tiofen-2-karboksamidi; organska sinteza; UV/Vis fluorimetrijska i NMR spektroskopija; kemosenzori; pH
• Keywords (english): benzo[b]thieno-2-carboxamides; organic synthesis; UV/Vis fluorimetric and NMR spectroscopy; chemosensors; pH
• Language: croatian
• URN:NBN: urn:nbn:hr:149:282381
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-02-02 13:07:34