Spektroskopska ispitivanja novih fluorescentnih probi temeljenih na benzimidazolu za određivanje pH i metalnih iona

master's thesis

• Title (english): Spectroscopic evaluation of novel heterocycles based on benzimidazole in pH and metal ion sensing
• Author: Leo Dorogi
• Mentor: Svjetlana Krištafor (mentor)
• Committee member: Svjetlana Krištafor (predsjednik povjerenstva)
• Committee member: Ema Horak (član povjerenstva)
• Committee member: Marijana Hranjec (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2017-09-26, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry; Applied Chemistry

Abstract

Cilj ovog rada je predstavljanje derivata benzimidazola kao kemijskih senzora i klik kemije kao jednostavne, brze i pouzdane metode sinteze organskih spojeva. Osim toga u okviru rada provedena je sinteza i optička karakterizacija novog potencijalnog kemijskog senzora temeljenog na benzimidazolu sa 1,2,3-triazolnom poveznicom. Sinteza spoja 5 uspješno je provedena klik reakcijom terminalnog alkina i odgovarajućeg azida u jednom stupnju. Pripravljenom spoju ispitane su spektroskopske karakteristike UV/Vis apsorpcijskom i fluorescencijskom emisijskom spektroskopijom u otapalima različite polarnosti. Da bi se ispitala mogućnost korištenja novo pripravljenog spoja kao pH senzora, provedena su spektroskopska ispitivanja u otopinama univerzalnog pufera u rasponu pH od 1 do 13. Ispitan je i utjecaj različitih metalnih iona na spektroskopske karakteristike spoja 5. Sintetizirani spoj 5 potencijalni je pH senzor u području pH od 6 – 9, osim toga spoj reagira sa svim ispitivanim metalima te stoga nije potencijalni senzor za ione metala.

Abstract (english)

Aim of this work is to present benzimidazole derivatives as chemical sensors and click chemistry as simple, fast and reliable method of organic synthesis. The synthesis and optical characterisation of new potential chemical sensor based on benzimidazole with 1,2,3-triazole link is also presented. Synthesis of compound 5 was successfully carried out by click reaction between terminal alkyne and azide in one step. Synthesised compound has been characterised by UV/Vis absorption and fluorescence emission spectroscopy in solutions with different polarity. To test the use of the new compound as pH sensor, it was tested in solutions of universal buffer in pH range of 1 – 13. The compound was also tested in solutions of different metal ions. Compound 5 was proven to be a potential sensor for pH in range of 6 – 9, besides that compound 5 interacts with all tested metal ions and therefore is not a potential sensor for metal ions.

• Keywords: 1 2 3-triazol; benzimidazol; kemijski optički senzor; fluorescencija; klik kemija
• Keywords (english): 1 2 3-triazole; benzimidazole; optical chemical sensor; fluorescence; click chemistry
• Language: croatian
• URN:NBN: urn:nbn:hr:149:120424
• Study programme: Title: Applied Chemistry - Graduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Advanced materials and technologies; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra primijenjene kemije (magistar/magistra primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-04-23 14:36:44