Priprava antibakterijskog elektroispredenog nosača za uzgoj stanica kože

master's thesis

• Title (english): Preparation of antibacterial electrospun scaffold for skin cells
• Author: Matea Večerić
• Mentor: Emi Govorčin Bajsić (mentor)
• Committee member: Emi Govorčin Bajsić (predsjednik povjerenstva)
• Committee member: Ljerka Kratofil Krehula (član povjerenstva)
• Committee member: Budimir Mijović (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2018-07-02, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering; Chemical Engineering in Material Development

Abstract

U ovom radu istražena je uloga i primjena titanijevog dioksida kao punila u elektroispredenom vlaknastom PCL/TiO2 nosaču. Titanij dioksid naknadno je nanesen pomoću ultrazvučne kupelji, na već elektroispredeni polimerni mat čistog PCL-a i mat PCL-a čija je površina tretirana s NaOH. Proces modifikacije površine elektroispredenog vlaknastog nosača od poli(ε-kaprolaktona) (PCL-a) proveden je kako bi se ostvarila bolja interakcija površine PCL-a s česticama TiO2. Korišten je tretman s NaOH kako bi se stvorile karboksilne funkcionalne skupine na površini vlaknastog polimera. Zatim je mjeren kontaktni kut goniometrom kako bi se dokazala promjena površine polimera od hidrofobne do hidrofilne, snimljene su SEM mikrografije, DSC tehnikom određena su toplinska svojstva te toplinska stabilnost termogravimetrijskom analizom.

Abstract (english)

In this work function and application of titanium dioxide as a filler in a composite system PCL/TiO2 was examined. Titanium dioxide was applied by ultrasonic device on already electrospun polymer scaffold non-treated and treated with NaOH. A procedure for the surface modification of electrospun poly(ε-caprolaktone) (PCL) fibrous scaffold was made to enhance the interaction of the PCL surface with TiO2 particles. The surface modification was performed using NaOH treatment for the formation of carboxyl groups on the fiber surfaces. Contact angle was measured by goniometer machine to prove change from hydrophobic to hydrophilic polymer surface. After that, SEM images were taken. Thermal properties were obtained by differential scanning calorimetry, as well as thermal stability was measured by thermogravimetric analysis.

• Keywords: elektroispredanje; polikaprolakton; titanijev dioksid; vlaknasti nosači; modifikacija površine
• Keywords (english): electrospinning; polycaprolactone; titan dioxide; scaffold; surface modification
• Language: croatian
• URN:NBN: urn:nbn:hr:149:575997
• Study programme: Title: Materials Science and Engineering - Graduate study; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka kemijskog inženjerstva (magistar/magistra inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-05-08 07:46:15