Određivanje konstanti disocijacije izabranih farmaceutika spektrofotometrijskom metodom

undergraduate thesis

• Title (english): Determination of dissociation constants of selected pharmaceuticals using spectrophotometric
• Author: Magdalena Ondrušek
• Mentor: Sandra Babić (mentor)
• Committee member: Sandra Babić (predsjednik povjerenstva)
• Committee member: Dragana Vuk (član povjerenstva)
• Committee member: Martina Biošić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2018-09-06, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry; Analytic Chemistry

Abstract

U ovom radu određene su konstante disocijacije (KK) šest farmaceutika (nitrofurantoin, sulfametazin, hidroksiklorokin, cefdinir, metoklopramid i trimetoprim) spektrofotometrijskom metodom. Korišteni su puferi ionske jakosti 0,1 mol/L s rasponom pH-vrijednosti od 3,45 – 10,11. Spektofotometrijskom analizom dobivene su ovisnosti apsorbancije o pH-vrijednosti za svaki farmaceutik iz kojih je određena pKK vrijednost pronalaženjem točke infleksije. Rezultati pokazuju da svi ispitivani farmaceutici imaju jednu konstantu disocijacije čije su pKK-vrijednosti između 7 i 10. Dobivene vrijednosti konstanti uspoređene su s literaturnim podacima. Određene konstante disocijacije farmaceutika omogućiti će bolje razumijevanje ponašanja farmaceutika u okolišu i brži razvoj metoda njihova određivanja.

Abstract (english)

In this work the acid dissociation constants (Ka) of six pharmaceuticals (nitrofurantoine, sulfamethazine, hydroxychloroquine, cefdinir, metoclopramide and trimethoprim) were determined by spectrophotometric method. The pH of the buffers was in the range 3.45 – 10.11 pH units, with ionic strength of 0.1 mol/L. Based on the results of spectrophotometric measurement, correlation between absorbance and pH was determined for each pharmaceutical. The pKa value was determined by finding inflection point. Results indicate that the pKa values for all pharmaceuticals are approximately between 7 and 10. In addition, the values obtained in this work are compared with the pKa’s available in literature determined by various techniques. These results are expected to facilitate the understanding on occurrence, fate and effects of pharmaceuticals in the environment and analytical methods development.

• Keywords: farmaceutici; konstanta disocijacije; spektrofotometrijska metoda
• Keywords (english): pharmaceuticals; acid dissociation constant; spectrophotometric method
• Language: croatian
• URN:NBN: urn:nbn:hr:149:407725
• Study programme: Title: Materials Science and Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-06-24 10:59:52