Poboljšanje topljivosti lijeka primjenom sušenja s raspršivanjem

undergraduate thesis

• Title (english): Solubility enhancement of drug by spray drying
• Author: Iva Andrić
• Mentor: Krunoslav Žižek (mentor)
• Committee member: Krunoslav Žižek (predsjednik povjerenstva)
• Committee member: Gordana Matijašić (član povjerenstva)
• Committee member: Stanislav Kurajica (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2018-09-21, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering; Mechanical, Thermal and Separation Processes

Abstract

U ovom eksperimentalnom istraživanju nastoji se pripremiti stabilna čvrsta disperzija lurasidon hidroklorida i polietilen glikola. Lurasidon hidroklorid djelatna je tvar kojom se liječe psihičke bolesti. Vrlo je slabe topivosti u vodenom mediju, ali vrlo dobre permeabilnosti kroz membranu. Zbog navedenih svojstva, prevođenje lijeka iz kristalne u amorfnu strukturu pripravom čvrste disperzije od velike je važnosti za bioraspoloživost samog lijeka. Pripremljena otopina kristalnog lurasidon hidroklorida i polietilen glikola u sustavu vode i etanola sušena je raspršivanjem. Definirani su optimalni procesni uvjeti sušenja. Izlazni procesni tok interpretiran je i okarakteriziran trima analitičkim metodama. Ustanovljene su strukturne karakteristike čvrstog disperznog sustava. Rezultati ukazuju da sušenjem s raspršivanjem nastaju čvrste disperzije nepromijenjenog faznog sastava.

Abstract (english)

In this experimental study, there is an effort to prepare a stable solid dispersion of lurasidone hydrochloride and polyethylene glycol. Lurasidone hydrochloride is an active substance for treatment of mental illness. It is of very low solubility in aqueous media, but of very good permeability through membrane. Because of the mentioned properties, converting the drug from crystalline to amorphous structure by making a solid dispersion is of great importance for the bioavailability of the drug itself. Prepared solution of crystalline lurasidone hydrochloride and polyethylene glycol in the system of water and ethanol is spray dried. Optimum process conditions for drying have been defined. Outlet process stream is interpreted and characterized by three analytical methods. The structural characteristics of solid dispersion system are established. The results indicate that spray drying results in solid dispersions of an unchanged phase structure.

• Keywords: lurasidon hidroklorid; polietilen glikol; loša topljivost lijeka; čvrsta disperzija; sušenje s raspršivanjem
• Keywords (english): lurasidone hydrochloride; polyethylene glycol; low drug solubility; solid dispersion; spray drying
• Language: croatian
• URN:NBN: urn:nbn:hr:149:509685
• Study programme: Title: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Applied organic chemistry; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-07-08 13:13:22