Sprega metode uklanjanja otapala i taljenja za pripravu čvrste disperzije djelatne tvari

undergraduate thesis

• Title (english): Coupling solvent removal and fusion method to prepare solid dispersion of drug
• Author: Melani Adamić-Golić
• Mentor: Krunoslav Žižek (mentor)
• Committee member: Krunoslav Žižek (predsjednik povjerenstva)
• Committee member: Irena Škorić (član povjerenstva)
• Committee member: Vesna Ocelić Bulatović (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2022-09-09, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Lurasidon-hidroklorid je antipsihotik koji se koristi za liječenje shizofrenije i bipolarnog poremećaja. Karakterizira ga slaba topljivost u intestinalnim fluidima, a time i slaba apsorpcija djelatne tvari u organizmu. Povećanje topljivosti lurasidon-hidroklorida, te samim time i bioraspoloživosti lijeka, znači bolje farmakološko djelovanje u liječenju psihičkih bolesti. Obećavajući pristup povećanju topljivosti, slabo topljivih, djelatnih tvari je priprava čvrstih disperzija. U ovom radu, čvrste disperzije hidrofobnog lurasidon-hidroklorida, u hidrofilnom, polimernom nosaču poli(etilen-glikolu), pripravljaju se u različitim omjerima spregom metode uklanjanja otapala i taljenja. Dobivene čvrste disperzije karakterizirane su diferencijalnom pretražnom kalorimetrijom, rendgenskom difrakcijskom analizom praha i infracrvenom spektroskopijom. Spektroskopske analize potvrđuju da nema amorfizacije za ovu metodu priprave niti međumolekulskih interakcija između lurasidon-hidroklorida i poli(etilen-glikola). Toplinska analiza dokazala je postojanje različitih kristalnih formi u čvrstim disperzijama.

Abstract (english)

Lurasidone hydrochloride is an antipsychotic drug used for the treatment of shizophrenia and bipolar disorder. It is characterized by low solubility in intestinal fluids and thus poor absorption of drug in the organism. Solubility improvement of lurasidone hydrochloride and thus the bioavaliability of drug, means its better pharmacological response in the treatment of psychotic disorders. Promising approach for drug solubility enhacement of poorly soluble drugs is preparation of solid dispersions. In this research, solid dispersions of hydrophobic lurasidone-hydrochloride in a hydrophilic polymer carrier poly(ethylene glycol), are to be made, in different ratios, by coupling solvent removal and fusion method. Obtained solid dispersions were characterized by differential scanning calorimetry, X-ray powder difraction analysis and infrared spectroscopy. Spectroscopic analyses confirmed that there is no amorphization for this preparation method and there is no intermolecular interactions between lurasidone-hydrochloride and poly(ethylene glycol). Thermal analysis proved the existence of different crystalline forms in solid dispersions.

• Keywords: lurasidon-hidroklorid; poboljšanje topljivosti lijeka; čvrsta disperzija; metoda uklanjanja otapala i taljenja
• Keywords (english): lurasidone hydrochloride; drug solubility improvement; solid dispersion; coupling solvent removal and fusion method
• Language: croatian
• URN:NBN: urn:nbn:hr:149:325515
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2022-09-09
• Created on: 2023-02-17 13:04:03