In vitro ispitivanje 3D-tiskanih kapsula

undergraduate thesis

• Title (english): In vitro study of 3D-printed capsules
• Author: Inga Geršak
• Mentor: Gordana Matijašić (mentor)
• Committee member: Gordana Matijašić (predsjednik povjerenstva)
• Committee member: Domagoj Vrsaljko (član povjerenstva)
• Committee member: Irena Škorić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2020-09-16, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

3D-tiskani oralni dozirni oblici nalaze sve veću primjenu u farmaceutskoj industriji zbog male cijene i mogućnosti personaliziranja lijekova. Da bi se kruti dozirni oblici mogli staviti u upotrebu potrebno je provesti in vitro ispitivanje oslobađanja kako bi se osigurala kvaliteta konačnog proizvoda. U radu je ispitano in vitro ponašanje 3D-tiskanih kapsula. Mijenjana je debljina stijenke čepa kapsule te je ispitano kako ona utječe na vrijeme oslobađanja sadržaja. Test je proveden s bojilima u uvjetima koji simuliraju in vitro uvjete. Odabrana je kapsula debljine stijenke 1 mm te su provedena in vitro ispitivanja oslobađanja biljnih ekstrakata origana, kadulje, timijana i ružmarina. Profili oslobađanja izraženi su promjenom antioksidacijskog kapaciteta, antioksidacijske aktivnosti i sadržaja ukupnih fenola. Korištene su metode FRAP, DPPH i UF te su dobiveni profili oslobađanja za svaki ekstrakt. Prema rezultatima dobivenima FRAP metodom oslobađanje ekstrakata iz 3D-tiskanih kapsula može se opisati kao odgođeno oslobađanje. Profili oslobađanja ekstrakata, odnosno antioksidacijskog kapaciteta, opisani su novim modelom izvedenim modificiranjem Higuchijevog kinetičkog modela.

Abstract (english)

3D-printed oral dosage forms are increasingly used in the pharmaceutical industry due to their low cost and suitability for drug personalization. In vitro release test must be performed to ensure the quality of the final product before commercialization. The in vitro behavior of 3D-printed capsules was investigated. The influence of wall thickness of the capsule cap on the lag time was examined. The test was performed by using dyes under simulation of in vitro conditions. A 1 mm thick wall capsule cap was selected and in vitro release studies of herbal extracts of oregano, sage, thyme and rosemary were performed. Release profiles are expressed by changes in antioxidant capacity, antioxidant activity and total phenolic content. FRAP, DPPH and UF methods were used and release profiles were obtained for each extract. According to the results obtained by the FRAP method, the release of extracts from 3D-printed capsules can be described as delayed release. A new model derived from the Higuchi kinetic model was used to describe extract release profiles, i.e. antioxidant capacity.

• Keywords: 3D-tisak; biljni ekstrakti; Higuchijev model; odgođeno oslobađanje
• Keywords (english): 3D print; herbal extracts; Higuchi model; delayed release
• Language: croatian
• URN:NBN: urn:nbn:hr:149:131455
• Study programme: Title: Materials Science and Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-03 13:32:09