Sinteza silicijem dopiranog vaterita

undergraduate thesis

• Title (english): Synthesis of silicon doped vaterite
• Author: Lucija Pavić
• Mentor: Hrvoje Ivanković (mentor)
• Committee member: Hrvoje Ivanković (predsjednik povjerenstva)
• Committee member: Nevenka Vrbos (član povjerenstva)
• Committee member: Stjepan Milardović (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2020-09-07, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Inženjerstvo koštanog tkiva je interdisciplinarno polje koje uključuje pripravu okosnica koje kemijski, strukturno i mehanički oponašaju prirodno koštano tkivo. Okosnice moraju biti biokompatibilne i bioaktivne uz zadovoljavajuća resorpcijska svojstva te predstavljaju alternativno rješenje za konvencionalne metode korištene u liječenju koštanih oštećenja i bolesti. Silicij se prirodno nalazi u ljudskom organizmu te potiče proliferaciju i diferencijaciju koštanih stanica te time pridonosi bržoj obnovi prirodnog koštanog tkiva. U ovom radu pripravljeni su uzorci kalcijeva karbonata dopirani različitom količinom silicija, koji će u daljnjim istraživanjima biti korišten kao prekursor hidroksiapatitu, mineralnoj fazi prirodnog koštanog tkiva. Pripremljeni uzorci toplinski su obrađeni pri 600 °C. Uzorci su karakterizirani prije i nakon toplinske obrade pomoću rendgenske difrakcijske analize (XRD) i infracrvene spektroskopije s Fourierovom transformacijom (FTIR). Dobiveni difraktogrami analizirani su Rietveldovom metodom utočnjavanja pomoću računalnog programa DIFFRAC. SUITE TOPAS V.5.0. Potvrđeno je nastajanje trofaznog sustava kalcita, aragonita i vaterita, dok nakon toplinske obrade nastaje sustav kalcita i kalcijeva silikata.

Abstract (english)

Bone tissue engineering is an interdisciplinary field where biomimetic scaffolds are used for bone regeneration. Biomimetic scaffolds chemically, structurally and mechanically imitate natural bone tissue. Scaffolds must be biocompatible and bioactive with suitable resorption properties. Biomimetic scaffolds represent an alternative solution for conventional methods that are used in the treatment of bone injuries and diseases. Silicon naturally exists in the human body and promotes proliferation and the differetiation of osteoblasts, thus it promotes regeneration of natural bone tissue. In this research, samples of calcium carbonate are synthesised with a different amount of silicon dopant which will be used as a precursor of hydroxyapatite, a mineral phase of natural bone tissue. All as-prepared samples are heat-treated at 600 °C. Samples are characterized before and after heat treatment with X-ray diffraction analysis (XRD) and infrared spectroscopy with Fourier transformations (FTIR). The software DIFFRAC. SUITE TOPAS V.5.0., with the fundamental parameters approach, was employed for Rietveld refinements. As-prepared samples are triphase systems of calcite, aragonite, and vaterite, while after heat treatment system is composed of calcite and calcium silicate.

• Keywords: biomaterijali; silicij; kalcijev karbonat; hidroksiapatit
• Keywords (english): biomaterials; silicon; calcium carbonate; hydroxyapatite
• Language: croatian
• URN:NBN: urn:nbn:hr:149:000419
• Project: Number: IP-2014-09-3752; Title: Razvoj biokompatibilnih materijala na temelju hidroksiapatita za primjene u inženjerstvu koštanog tkiva; Title: Development of Biocompatible Hydroxyapatite Based Materials for Bone Tissue Engineering Applications; Acronym: HaTEA; Leader: Hrvoje Ivanković; Jurisdiction: Croatia; Funder: HRZZ; Funding stream: IP
• Study programme: Title: Materials Science and Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-08 09:51:44