Desorpcija hidroksiklorokina i metoklopramida s prirodnih uzoraka tla

undergraduate thesis

• Title (english): Desorption of hydroxychloroquine and metoclopramide from natural soil samples
• Author: Ema Pavić
• Mentor: Dragana Mutavdžić Pavlović (mentor)
• Committee member: Dragana Mutavdžić Pavlović (predsjednik povjerenstva)
• Committee member: Šime Ukić (član povjerenstva)
• Committee member: Lidija Furač (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2019-09-18, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Hidroksiklorokin je imunomodulatorni lijek koji se već 60 godina koristi za liječenje malarije i autoimunih bolesti. S druge strane, metoklopramid spada u skupinu antiemetika, lijekova koji se koriste za prevenciju povraćanja i liječenje njegovih posljedica. Jednom kad ovi farmaceutici dospiju u tlo, mogu stupiti u interakciju s različitim komponentama tla ili mogu biti isprani u površinske ili podzemne vode. Stoga je, kako bi se spriječilo zagađenje okoliša, potrebno poznavati mehanizme kojima se farmaceutici zadržavaju i oslobađaju iz tla. U ovom radu ispitana je desorpcija hidroksiklorokina i metoklopramida s 5 uzoraka tala prikupljenih na području Republike Hrvatske. Ispitan je mehanizam kinetike desorpcije te utjecaj ionske jakosti i pH vrijednosti standardnih otopina farmaceutika na njihovu desorpciju. Desorpcija hidroksiklorokina prikazana je Freundlichovim i Temkinovim modelom na temelju kojih su određeni parametri sorpcije. Koeficijent raspodjele, Kd, za ispitivana tla kreće se u rasponu od 3909,4 mL/g do 7122,1 mL/g. Desorpcija metoklopramida opisana je Freundlichovim i Dubinin-Raduskevichevim modelom, a koeficijent raspodjele kreće se u rasponu od
27,299 mL/g do 594,63 mL/g. Kinetiku desorpcije najbolje opisuje model pseudo-drugog reda. Ispitivanjem utjecaja ionske jakosti i pH pokazalo se da se kapacitet sorpcije smanjuje s porastom ionske jakosti otopine CaCl2 kao i s njezinom pH vrijednosti.

Abstract (english)

Hydroxychloroquine is an immunomodulatory drug that has been used for 60 years to treat malaria and autoimmune diseases. On the other hand, metoclopramide belongs to a group of antiemetics, medicines used to prevent vomiting and treat its consequences. Once this pharmaceuticals present in manure, they may interact with different soil components or may be washed off into surface water or leached to ground water. Therefore, to prevent water contamination it is necessary to understand the mechanisms by which pharmaceuticals are retained and released from soil. In this study, the mechanism of desorption of hydroxychloroquine and metoclopramide from natural soils samples from Croatia is examined. Kinetics of desorption, the impact of ionic strength and the influence of pH on their`s desorption are studied. In order to determine the desorption mechanisms of hydroxychloroquine, Freundlich and Temkin isotherm model are applied by which certain parameters of desorption are determined. The obtained distribution coefficient, Kd, for tested soils is in range of 3909.4 mL/g to 7122.1 mL/g. Desorption of metoclopramide is shown by Freundlich and Dubinin-Radushkevich isotherms. For five soil samples, distribution coefficient is ranged from 27.299 mL/g to 594.63 mL/g. The rate of desorption is the best described with the kinetic model of pseudo-second order. Investigating the influence of ionic strength and pH, the results show that the values of sorption coefficient decreased with the increase in ionic strength of CaCl2 solution as well with its pH value.

• Keywords: hidroksiklorokin; metoklopramid; tlo; desorpcija; ionska jakost; pH
• Keywords (english): hydroxychloroquine; metoclopramide; soil; desorption; ionic strength; pH
• Language: croatian
• URN:NBN: urn:nbn:hr:149:002829
• Project: Number: IP-2014-09-2353; Title: Sudbina farmaceutika u okolišu i tijekom naprednih postupaka obrade voda; Title: Fate of pharmaceuticals in the environment and during advanced wastewater treatment; Acronym: PharmaFate; Leader: Sandra Babić; Jurisdiction: Croatia; Funder: HRZZ; Funding stream: IP
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-26 10:47:43