Primjena prirodnih niskotemperaturnih eutektičkih otapala za poboljšanje topljivosti djelatne tvari

undergraduate thesis

• Title (english): Application of natural deep eutectic solvents for improvement of active pharmaceutical ingredient's solubility
• Author: Dragana Pacina
• Mentor: Jasna Prlić Kardum (mentor)
• Committee member: Jasna Prlić Kardum (predsjednik povjerenstva)
• Committee member: Aleksandra Sander (član povjerenstva)
• Committee member: Dajana Kučić Grgić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2024-09-04, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering

Abstract

Niskotemperaturna eutektička otapala nova su klasa otapala dobivena jednostavnim miješanjem najmanje dviju komponenti, donora i akceptora vodikove veze. Karakterizira ih značajno snižena temperatura tališta u odnosu na tališta čistih komponenata, nizak tlak para i veća gustoća od gustoće vode. Zbog povoljnih fizikalno-kemijskih svojstava u farmaceutskoj se industriji koriste za poboljšanje topljivosti, permeabilnosti, stabilnosti i apsorpcije djelatne tvari, što vodi do povećanja bioraspoloživosti. U ovome su radu pripremljena i karakterizirana niskotemperaturna eutektička otapala nastala miješanjem različitih netoksičnih komponenata u određenim omjerima. U tako pripremljena otapala dodana je određena masa djelatne tvari, ceritiniba. Cilj je dobiti stabilno niskotemperaturno otapalo boljih svojstava koje će povećati topljivost djelatne tvari. Pripremljenim otapalima određena su gustoća, viskoznost i pH vrijednost. Kako bi se potvrdio nastanak vodikovih veza među komponentama, provedena je analiza na infracrvenom spektrofotometru s Fourierovom transformacijom. Primjenom UV/VIS spektrofotometrijske analize i određivanjem indeksa loma na refraktometru praćena je koncentracija pri ispitivanju topljivosti ceritiniba.

Abstract (english)

Deep eutectic solvents are a new class of solvents obtained by simply mixing at least two components, a hydrogen bond donor and an acceptor. They have a significantly lower melting point than pure components, a lower vapor pressure and a higher density than water. As a result of their physicochemical characteristics, they are utilized in the pharmaceutical industry to enhance drug solubility, permeability, stability and absorption, which leads to increased bioavailability. This paper prepared and characterized deep eutectic solvents by mixing different non-toxic components in a specific molar ratio. A certain amount of an active pharmaceutical ingredient, ceritinib, was added to the prepared solvents. The purpose of the work is to prepare a stable, deep eutectic solvent with better properties that will increase the solubility of an active pharmaceutical ingredient. The densities, viscosities, and pH values of the prepared solvents were determined. In order to confirm the formation of hydrogen bonds between the mixed components, an analysis was performed on an infrared spectrofotometer with Fourier transformation. The solubility of ceritinib was tested by measuring its concentration using refractive index and UV/VIS spectrofotometric analysis.

• Keywords: ceritinib; djelatna tvar; terapeutsko niskotemperaturno eutektičko otapalo; topljivost
• Keywords (english): ceritinib; active pharmaceutical ingredient; therapeutic deep eutectic solvent; solubility
• Language: croatian
• URN:NBN: urn:nbn:hr:149:903478
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-10-14 11:08:29