Antimikrobne prevlake temeljene na nanočesticama metala i metalnih oksida

master's thesis

• Title (english): Antimicrobial coatings based on metal and metal oxide nanoparticles
• Author: Katja Čemerin
• Mentor: Ernest Meštrović (mentor)
• Mentor: Iva Rezić Meštrović (komentor)
• Committee member: Ernest Meštrović (predsjednik povjerenstva)
• Committee member: Petar Kassal (član povjerenstva)
• Committee member: Iva Rezić Meštrović (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2024-09-30, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Bakar je jedan od najpoznatijih antimikrobnih metala povezan s različitim antimikrobnim mehanizmima kao što su: permeabilizacija plazma membrane, lipidna peroksidacija membrane, izmjena proteina, inhibicija sastavljanja i aktivnosti proteina ili denaturacija nukleinskih kiselina. Nadalje, bakar u obliku nanomaterijala pokazuje veću antimikrobnu aktivnost te predstavlja novu klasu nano-antimikrobnih sredstava koja pružaju dodatne učinke i karakteristike u usporedbi s često korištenim nanočesticama srebra ili cinkovog oksida. Vlakna, pređe i drugi materijali obogaćeni nanočesticama bakra mogu se koristiti u različitim biomedicinskim i tekstilnim primjenama kao što su medicinski uređaji, zavoji za opekline ili rane, zdravstveni materijali (uključujući proizvode za jednokratnu upotrebu), proizvodi za osobnu njegu, veterinarski proizvodi, vojne i bio-obrambene stavke, zaštitna odijela ili odjeća. Ovaj rad stoga predstavlja primjenu Cu nanočestica u funkcionalizaciji površine medicinskog materijala. Biokompatibilne pređe dobivene elektropredenjem modificirane su primjenom sol-gel postupka tijekom kojeg su Cu nanočestice ugrađene u antimikrobne prevlake. Materijali su karakterizirani prije i nakon modifikacije pomoću FTIR, UV-VIS, SEM i DLS metoda. Rezultati su dokazali učinkovitu tvorbu novog antimikrobnog premaza koji je homogeno raspoređen na površini pređe. Osim toga, antimikrobni testovi Cu nanočestica dokazali su antimikrobno svojstvo Cu nanočestica u prevlakama, omogućujući buduću primjenu biopolimera kao novih medicinskih materijala.

Abstract (english)

Copper is one of the most widely recognized antimicrobial metal linked to multiple antimicrobial mechanisms such as: plasma membrane permeabilization, membrane lipid peroxidation, alteration of proteins, inhibition of protein assembly and activity, or denaturation of nucleic acids. Moreover, copper in a form of nanomaterials shows grater antimicrobial activity so is an emerging class of nano-antimicrobials providing complimentary effects and characteristics, as compared to widely used silver or zinc oxide nanoparticles. Metal nanoparticle-loaded yarns can be used in a number of biomedical and textile applications such as medical devices, burn or wound dressings, healthcare materials (including disposables), personal care products, veterinary, military and bio-defense items, protective suits or clothing. This work therefore presents application of Cu nanoparticles in functionalization of the surface of medical material by deep coating method. Electrospun biocompatible yarns were modified by using sol-gel procedure during which the Cu nanoparticles were incorporated within the coating. The materials were characterized before and after the modification by FTIR, UV-VIS, SEM and DLS methods. The results proved efficient formation of a novel antimicrobial coating homogeneously distributed on the surface of the yarns. Additionally, antimicrobial tests of Cu nanoparticles proved the antimicrobial property of Cu nanoparticles in coating, enabling future application of novel medical materials.

• Keywords: bakar; nanočestice; sol-gel postupak; FTIR; UV-VIS; SEM i DLS
• Keywords (english): copper; nanoparticles; sol-gel procedure; FTIR; UV-VIS; SEM; DLS
• Language: croatian
• URN:NBN: urn:nbn:hr:149:880895
• Study programme: Title: Environmental Engineering - Graduate study; Study programme type: university; Study level: graduate; Academic / professional title: sveučilišni/a magistar/magistra inženjer/inženjerka ekoinženjerstva (sveučilišni/a magistar/magistra inženjer/inženjerka ekoinženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-11-11 15:33:05