Sinteza biološki aktivnih konjugata cijano-supstituiranih heterocikla i 1,2,3-triazola

undergraduate thesis

• Title (english): Synthesis of biologically active conjugates of cyano-substituted heterocycles and 1,2,3-triazoles
• Author: Marko Krklec
• Mentor: Silvana Raić-Malić (mentor)
• Committee member: Silvana Raić-Malić (predsjednik povjerenstva)
• Committee member: Andrijana Meščić (član povjerenstva)
• Committee member: Lidija Furač (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2016-09-23, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry; Organic Chemistry

Abstract

Cilj rada bio je sintetizirati nove konjugate aromatskih nitrila i odabranih heterocikla (derivata kumarina, kromona, kinolina, indola, benzotiazola) povezanih 1,2,3-triazolnom poveznicom kako bi se dobili novi spojevi s boljim farmakološkim svojstvima. Triazolni prsten uveden je 1,3-dipolarnom cikloadicijom kataliziranom bakrom 4-azidobenzonitrila i odgovarajućeg termalnog alkina. Strukture novopriređenih spojeva potvrđene su spektroskopijom 1H i 13C NMR i rendgenskom strukturnom analizom.

Abstract (english)

Aim of this work was to synthesize novel conjugates of aromatic nitriles and selected heterocycles (derivatives of coumarin, chromone, quinoline, indole, benzothiazole) linked via 1,2,3-triazole spacer to obtain new compounds with improved pharmacological properties. The triazole ring is introduced by copper-catalyzed 1,3-dipolar cycloaddition (CuAAC) of 4-azidobenzonitrile and appropriate therminal alkynes. The structures of compounds have been confirmed by 1H- and 13C-NMR spectroscopy and X-ray crystallographic analysis.

• Keywords: 1 2 3-triazoli; "klik" kemija; heterocikli; molekulska hibridizacija
• Keywords (english): 1 2 3-triazoles; "click" chemistry; heterocycles; molecular hybridization
• Language: croatian
• URN:NBN: urn:nbn:hr:149:246859
• Study programme: Title: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Applied organic chemistry; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-02-16 13:48:54